The role of stress in mediating inflammation in the context of neurodegeneration
Abstract
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is observed in numerous neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). In conjunction, epidemiological studies have found chronic stress to be a risk factor for these diseases, suggesting a role for stress and the HPA axis in disease onset or progression. The HPA axis and the major stress hormone cortisol are known to be potent modulators of inflammation. Importantly neuroinflammation is a common feature across these neurodegenerative diseases. This chapter therefore discusses how stress and dysregulation of the HPA axis impact inflammatory cells such as microglia, astrocytes, and infiltrating monocytes to promote neurodegenerative processes.
Document Type
Book Chapter
Date of Publication
1-1-2024
Volume
5
Publication Title
Stress: Immunology and Inflammation
Publisher
Elsevier
School
School of Medical and Health Sciences
RAS ID
62723
Copyright
subscription content
First Page
325
Last Page
337
Comments
Armstrong, A. M., Woodfield, A., Eccles, M., Groth, D., & Verdile, G. (2024). The role of stress in mediating inflammation in the context of neurodegeneration. In G. Fink (Ed.), Stress: Immunology and Inflammation (pp. 325-337). Elsevier. https://doi.org/10.1016/B978-0-12-817558-3.00005-6