The role of stress in mediating inflammation in the context of neurodegeneration

Document Type

Book Chapter

Publication Title

Stress: Immunology and Inflammation

Volume

5

First Page

325

Last Page

337

Publisher

Elsevier

School

School of Medical and Health Sciences

RAS ID

62723

Comments

Armstrong, A. M., Woodfield, A., Eccles, M., Groth, D., & Verdile, G. (2024). The role of stress in mediating inflammation in the context of neurodegeneration. In G. Fink (Ed.), Stress: Immunology and Inflammation (pp. 325-337). Elsevier. https://doi.org/10.1016/B978-0-12-817558-3.00005-6

Abstract

Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is observed in numerous neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). In conjunction, epidemiological studies have found chronic stress to be a risk factor for these diseases, suggesting a role for stress and the HPA axis in disease onset or progression. The HPA axis and the major stress hormone cortisol are known to be potent modulators of inflammation. Importantly neuroinflammation is a common feature across these neurodegenerative diseases. This chapter therefore discusses how stress and dysregulation of the HPA axis impact inflammatory cells such as microglia, astrocytes, and infiltrating monocytes to promote neurodegenerative processes.

DOI

10.1016/B978-0-12-817558-3.00005-6

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