Document Type

Journal Article

Publication Title

Investigative Ophthalmology & Visual Science





First Page


PubMed ID



The Association for Research in Vision and Ophthalmology


School of Medical and Health Sciences / Centre for Precision Health




National Natural Science Foundation of China / Project from Beijing Municipal Education Commission


Guo, Y., Li, J., Tian, F., Hou, R., Liu, L., Duan, J., . . . Wu, L. (2023). Parapapillary βBM and γ zones played different roles in axial elongation among young adolescents using optical coherence tomography. Investigative Ophthalmology & Visual Science, 64(15), article 34.


Purpose: To evaluate the influencing factors of parapapillary BM and zones incidence in young adolescents and to explore their associations with axial length progression. Methods: In this prospective cohort study, 976 seventh-grade students from nine secondary schools in Beijing, China, were enrolled and followed up 1 year later. Parapapillary BM zone was defined as retinal pigment epithelium loss while Bruch's membrane was present. Parapapillary zone was defined as the absence of retinal pigment epithelium and Bruch's membrane. Logistic regression model was used to analyze the influencing factors of BM and zone incidence. A linear mixed model was used to analyze the associations between parapapillary zones and axial elongation. Results: Of the 976 participants, 139 (14.2%) had only BM zone, 398 (40.8%) had only zone, and 171 (17.5%) had both. At follow-up, the incidence of BM zone was 11.5% (76/659), and the incidence of zone was 9.7% (39/404). Optic disc tilt, thinner subfoveal choroid, and longer axial length at baseline showed a higher risk of zone incidence. The absence of zone at baseline showed a faster axial length progression. When the baseline axial length was 25 mm or longer, the BM zone was also related to the axial elongation. Conclusions: The zone was associated with axial length progression, and the BM zone was also associated with the axial length progression when the axial length exceeded 25 mm, which was consistent with the notion that excessive axial length growth not only is the extension of the eyeball but also has its own pathologic changes.



Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.