Abstract
Introduction: The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (A ) over 15 years in a cohort of cognitively unimpaired older adults. Methods: PA and A measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain A . Moderation analyses examined apolipoprotein E (APOE) 4 carriage impact on the PA-A relationship. Results: PA was not associated with brain A at baseline ( = –0.001, p = 0.72) or over time ( = –0.26, p = 0.24). APOE 4 status did not moderate the PA-A relationship over time ( = 0.12, p = 0.73). Brain A levels did not predict PA trajectory ( = –54.26, p = 0.59). Discussion: Our study did not identify a relationship between habitual PA and brain A levels. Highlights: Physical activity levels did not predict brain amyloid beta (A ) levels over time in cognitively unimpaired older adults ( ≥ 60 years of age). Apolipoprotein E (APOE) 4 carrier status did not moderate the physical activity–brain A relationship over time. Physical activity trajectories were not impacted by brain A levels.
Keywords
Alzheimer's disease, amyloid beta, dementia, exercise, genetics, longitudinal, physical activity
Document Type
Journal Article
Date of Publication
1-1-2023
Volume
20
Issue
2
Publication Title
Alzheimer's & Dementia
Publisher
Wiley
School
School of Medical and Health Sciences / Centre for Precision Health
RAS ID
64679
Funding Information
The study has received partial financial support from the Alzheimer's Association (USA), the Alzheimer's Drug Discovery Foundation, an anonymous foundation, the Science and Industry Endowment Fund, the Dementia Collaborative Research Centres, the Victorian Government's Operational Infrastructure Support program, the Australian Alzheimer's Research Foundation, the National Health and Medical Research Council (NHMRC), and The Yulgilbar Foundation. Numerous commercial interactions have supported data collection and analyses. In-kind support has also been provided by Sir Charles Gairdner Hospital, Cogstate Ltd., Hollywood Private Hospital, The University of Melbourne, and St. Vincent's Hospital. M.G.S is supported by a Research Training Program (RTP) scholarship. S.R.R.S. is supported by an NHMRC Investigator Grant (GNT1197315). This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Funding received from the National Health and Medical Research Council (NHMRC)
GNT1197315
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
First Page
1350
Last Page
1359
Recommended Citation
Slee, M. G., Rainey-Smith, S. R., Villemagne, V. L., Doecke, J. D., Sohrabi, H. R., Taddei, K., . . . Brown, B. M. (2023). Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults. Alzheimer's & Dementia, 20(2), 1350-1359. https://doi.org/10.1002/alz.13556
Comments
Slee, M. G., Rainey-Smith, S. R., Villemagne, V. L., Doecke, J. D., Sohrabi, H. R., Taddei, K., . . . Brown, B. M. (2023). Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults. Alzheimer's & Dementia, 20(2), 1350-1359. https://doi.org/10.1002/alz.13556