Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults

Authors

Michael G. Slee
Stephanie R. Rainey-Smith, Edith Cowan UniversityFollow
Victor L. Villemagne, Edith Cowan UniversityFollow
James D. Doecke
Hamid R. Sohrabi, Edith Cowan UniversityFollow
Kevin Taddei, Edith Cowan UniversityFollow
David Ames
Vincent Dore
Paul Maruff
Simon M. Laws, Edith Cowan UniversityFollow
Colin L. Masters
Christopher C. Rowe
Ralph N. Martins, Edith Cowan UniversityFollow
Kirk I. Erickson
Belinda M. Brown, Edith Cowan UniversityFollow

Document Type

Journal Article

Publication Title

Alzheimer's & Dementia

Publisher

Wiley

School

School of Medical and Health Sciences / Centre for Precision Health

RAS ID

64679

Funders

Alzheimer's Association / Alzheimer's Drug Discovery Foundation / Science and Industry Endowment Fund / Dementia Collaborative Research Centres / Victorian Government's Operational Infrastructure Support program / Australian Alzheimer's Research Foundation / National Health and Medical Research Council / Yulgilbar Foundation

Grant Number

NHMRC Number : GNT1197315

Grant Link

http://purl.org/au-research/grants/nhmrc/1197315

Comments

Slee, M. G., Rainey-Smith, S. R., Villemagne, V. L., Doecke, J. D., Sohrabi, H. R., Taddei, K., . . . Brown, B. M. (2023). Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults. Alzheimer's & Dementia. Advance online publication. https://doi.org/10.1002/alz.13556

Abstract

Introduction: The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (A ) over 15 years in a cohort of cognitively unimpaired older adults. Methods: PA and A measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain A . Moderation analyses examined apolipoprotein E (APOE) 4 carriage impact on the PA-A relationship. Results: PA was not associated with brain A at baseline ( = –0.001, p = 0.72) or over time ( = –0.26, p = 0.24). APOE 4 status did not moderate the PA-A relationship over time ( = 0.12, p = 0.73). Brain A levels did not predict PA trajectory ( = –54.26, p = 0.59). Discussion: Our study did not identify a relationship between habitual PA and brain A levels. Highlights: Physical activity levels did not predict brain amyloid beta (A ) levels over time in cognitively unimpaired older adults ( ≥ 60 years of age). Apolipoprotein E (APOE) 4 carrier status did not moderate the physical activity–brain A relationship over time. Physical activity trajectories were not impacted by brain A levels.

DOI

10.1002/alz.13556

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License