Document Type

Journal Article

Publication Title

Alzheimer's & Dementia




School of Medical and Health Sciences / Centre for Precision Health




Alzheimer's Association / Alzheimer's Drug Discovery Foundation / Science and Industry Endowment Fund / Dementia Collaborative Research Centres / Victorian Government's Operational Infrastructure Support program / Australian Alzheimer's Research Foundation / National Health and Medical Research Council / Yulgilbar Foundation

Grant Number

NHMRC Number : GNT1197315

Grant Link


Slee, M. G., Rainey-Smith, S. R., Villemagne, V. L., Doecke, J. D., Sohrabi, H. R., Taddei, K., . . . Brown, B. M. (2023). Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults. Alzheimer's & Dementia. Advance online publication.


Introduction: The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (A ) over 15 years in a cohort of cognitively unimpaired older adults. Methods: PA and A measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain A . Moderation analyses examined apolipoprotein E (APOE) 4 carriage impact on the PA-A relationship. Results: PA was not associated with brain A at baseline ( = –0.001, p = 0.72) or over time ( = –0.26, p = 0.24). APOE 4 status did not moderate the PA-A relationship over time ( = 0.12, p = 0.73). Brain A levels did not predict PA trajectory ( = –54.26, p = 0.59). Discussion: Our study did not identify a relationship between habitual PA and brain A levels. Highlights: Physical activity levels did not predict brain amyloid beta (A ) levels over time in cognitively unimpaired older adults ( ≥ 60 years of age). Apolipoprotein E (APOE) 4 carrier status did not moderate the physical activity–brain A relationship over time. Physical activity trajectories were not impacted by brain A levels.



Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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