Dietary vitamin K1 intake and incident aortic valve stenosis

Authors

Carl J. Schultz
Frederik Dalgaard
Jamie W. Bellinge
Kevin Murray
Marc Sim, Edith Cowan UniversityFollow
Emma Connolly, Edith Cowan UniversityFollow
Lauren C. Blekkenhorst, Edith Cowan UniversityFollow
Catherine P. Bondonno, Edith Cowan UniversityFollow
Joshua R. Lewis, Edith Cowan UniversityFollow
Gunnar H. Gislason
Anne Tjønneland
Kim Overvad
Jonathan M. Hodgson, Edith Cowan UniversityFollow
Nicola P. Bondonno, Edith Cowan UniversityFollow

Document Type

Journal Article

Publication Title

Arteriosclerosis, Thrombosis, and Vascular Biology

Volume

44

Issue

2

First Page

513

Last Page

521

PubMed ID

38152887

Publisher

American Heart Association, Inc.

School

Nutrition and Health Innovation Research Institute / School of Medical and Health Sciences

Comments

Schultz, C. J., Dalgaard, F., Bellinge, J. W., Murray, K., Sim, M., Connolly, E., . . . Bondonno, N. P. (2024). Dietary vitamin K1 intake and incident aortic valve stenosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 44(2), 513-521. https://doi.org/10.1161/ATVBAHA.123.320271

Abstract

BACKGROUND: Leaflet calcification contributes to the development and progression of aortic valve stenosis. Vitamin K activates inhibitors of vascular calcification and may modulate inflammation and skeletal bone loss. Therefore, we aimed to determine whether higher dietary intakes of vitamin K1are associated with a lower incidence of aortic stenosis. METHODS: In the Danish Diet, Cancer and Health study, participants aged 50 to 64 years completed a 192-item food frequency questionnaire at baseline, from which habitual intakes of vitamin K1were estimated. Participants were prospectively followed using linkage to nationwide registers to determine incident aortic valve stenosis (primary outcome) and aortic stenosis with subsequent complications (aortic valve replacement, heart failure, or cardiovascular disease-related mortality; secondary outcome). RESULTS: In 55 545 participants who were followed for a maximum of 21.5 years, 1085 were diagnosed with aortic stenosis and 615 were identified as having subsequent complications. Participants in the highest quintile of vitamin K1intake had a 23% lower risk of aortic stenosis (hazard ratio, 0.77 [95% CI, 0.63-0.94]) and a 27% lower risk of aortic stenosis with subsequent complications (hazard ratio, 0.73 [95% CI, 0.56-0.95]), compared with participants in the lowest quintile after adjusting for demographics and cardiovascular risk factors. CONCLUSIONS: In this study, a high intake of vitamin K1-rich foods was associated with a lower incidence of aortic stenosis and a lower risk of aortic stenosis with subsequent complications.

DOI

10.1161/ATVBAHA.123.320271

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