Dietary vitamin K1 intake and incident aortic valve stenosis
Author Identifier
Emma L. Connolly
https://orcid.org/0000-0003-0171-8236
Marc Sim
https://orcid.org/0000-0001-5166-0605
Lauren C. Blekkenhorst
https://orcid.org/0000-0003-1561-9052
Jonathan M. Hodgson
https://orcid.org/0000-0001-6184-7764
Catherine P. Bondonno
https://orcid.org/0000-0001-8509-439X
Nicola P. Bondonno
Document Type
Journal Article
Publication Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume
44
Issue
2
First Page
513
Last Page
521
PubMed ID
38152887
Publisher
American Heart Association, Inc.
School
Nutrition and Health Innovation Research Institute / School of Medical and Health Sciences
Funders
The Danish Diet, Cancer and Health study was funded by the Danish Cancer Society, Denmark. The salary of J.R. Lewis is supported by National Heart Foundation of Australia Future Leader Fellowship (ID: 102817). M. Sim is supported by Royal Perth Hospital Career Advancement Fellowship (ID: CAF130/2020), Emerging Leader Fellowship, and a project grant from the Western Australian Future Health and Innovation Fund. E. Connolly is supported by Edith Cowan University Australian Government Research Training Program Scholarship. L.C. Blekkenhorst is supported by the National Health and Medical Research Council of Australia Emerging Leadership Investigator Grant (ID: 1172987) and National Heart Foundation of Australia Post-Doctoral Research Fellowship (ID: 102498). The salary of C.P. Bondonno is supported by Royal Perth Hospital Research Foundation Lawrie Beilin Career Advancement Fellowship (ID: CAF127/2020).
Grant Number
NHMRC NUmbers : 102498, 1172987, CAF127/2020
Abstract
BACKGROUND: Leaflet calcification contributes to the development and progression of aortic valve stenosis. Vitamin K activates inhibitors of vascular calcification and may modulate inflammation and skeletal bone loss. Therefore, we aimed to determine whether higher dietary intakes of vitamin K1are associated with a lower incidence of aortic stenosis. METHODS: In the Danish Diet, Cancer and Health study, participants aged 50 to 64 years completed a 192-item food frequency questionnaire at baseline, from which habitual intakes of vitamin K1were estimated. Participants were prospectively followed using linkage to nationwide registers to determine incident aortic valve stenosis (primary outcome) and aortic stenosis with subsequent complications (aortic valve replacement, heart failure, or cardiovascular disease-related mortality; secondary outcome). RESULTS: In 55 545 participants who were followed for a maximum of 21.5 years, 1085 were diagnosed with aortic stenosis and 615 were identified as having subsequent complications. Participants in the highest quintile of vitamin K1intake had a 23% lower risk of aortic stenosis (hazard ratio, 0.77 [95% CI, 0.63-0.94]) and a 27% lower risk of aortic stenosis with subsequent complications (hazard ratio, 0.73 [95% CI, 0.56-0.95]), compared with participants in the lowest quintile after adjusting for demographics and cardiovascular risk factors. CONCLUSIONS: In this study, a high intake of vitamin K1-rich foods was associated with a lower incidence of aortic stenosis and a lower risk of aortic stenosis with subsequent complications.
DOI
10.1161/ATVBAHA.123.320271
Access Rights
subscription content
Comments
Schultz, C. J., Dalgaard, F., Bellinge, J. W., Murray, K., Sim, M., Connolly, E., . . . Bondonno, N. P. (2024). Dietary vitamin K1 intake and incident aortic valve stenosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 44(2), 513-521. https://doi.org/10.1161/ATVBAHA.123.320271