The effect of cumulative lipid accumulation product and related long-term change on incident stroke: The kailuan study
Document Type
Journal Article
Publication Title
Nutrition, Metabolism & Cardiovascular Diseases
Volume
34
Issue
4
First Page
980
Last Page
987
PubMed ID
38220505
Publisher
Elsevier
School
School of Medical and Health Sciences / Centre for Precision Health
RAS ID
65508
Abstract
Background and aims: A single measurement lipid accumulation product (LAP) level has been shown to increase cardiovascular disease, but cumulative LAP on stroke effects is uncertain. Methods and results: This study included 43,089 participants, free of any cardiovascular diseases at baseline, from the Kailuan Study. The cumulative LAP was determined by multiplying the average LAP index and the time interval between two consecutive examinations, resulting in their categorization into four quartile groups. The higher LAP exposure was defined as participants with LAP values exceeding 90% of this population during each health survey. The association between cumulative LAP and stroke was assessed using multivariable Cox proportional hazard models. During a median follow-up period of 11.0 (10.6–11.3) years, 2461 participants developed stroke (of which 2220 were ischemic stroke, 320 were hemorrhagic stroke, and 79 were concurrent). After adjusting for potential confounders, the risk of stroke gradually increased in Groups Q2 to Q4 compared to Q1, with hazard ratios (HRs) ranging from 1.19 (95% CI: 1.05–1.36) to 1.50 (95% CI: 1.30–1.70). Specifically, the risk of ischemic stroke showed an increase from 1.21 (1.06–1.39) to 1.56 (1.36–1.79), while no statistically significant effect was observed for hemorrhagic stroke. The longer duration of higher LAP index exposure was also associated with increased stroke risk. Similar results were obtained in the stratification and sensitivity analyses. Conclusion: Cumulative LAP was positively and significantly associated with incident stroke, especially ischemic stroke, and a longer duration of exposure to higher LAP may increase the risk of stroke.
DOI
10.1016/j.numecd.2023.12.003
Access Rights
subscription content
Comments
Zhou, H., Lan, Y., Wu, D., Chen, S., Ding, X., & Wu, S. (2024). The effect of cumulative lipid accumulation product and related long-term change on incident stroke: The kailuan study. Nutrition, Metabolism & Cardiovascular Diseases, 34(4), 980-987. https://doi.org/10.1016/j.numecd.2023.12.003