Document Type
Journal Article
Publication Title
Phytochemistry Reviews
Publisher
Springer
School
School of Medical and Health Sciences
RAS ID
70012
Funders
Open Access funding enabled and organized by CAUL and its Member Institutions
Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and most common cause of dementia among older people. The main pathological hallmarks of AD are formation of insoluble amyloid beta senile plaques and paired helical filaments of neurofibrillary tangles. AD features gradual memory decline, mild to severe cognitive impairment, eventually total dependence of patients on caregivers. Currently available drugs have not been able to modify AD pathology. This has drawn increasing attention to plant food materials with high nutritional and bioactive constituents as potential complementary therapy for AD. Sorghum bicolor is a widely available cost-effective source of proteins, fats, crude fibres, biopeptides and polyphenols which are vital for human wellbeing. This review discussed the major mechanisms underlying AD pathology. The nutritional and bioactive constituents of Sorghum bicolor grains were extensively described. There is limited report on anti-AD activities of sorghum grains. Therefore, the pharmacological mechanisms of action including scavenging of reactive oxygen species, inhibition of oxidative stress, anti-acetylcholinesterase activity and modulation of mitophagy were only speculated. This comprehensive update suggests more robust innovative studies that will provide critical theoretical details necessary to promote utilization of sorghum grains as functional food or source of bioactive molecules for AD therapy.
DOI
10.1007/s11101-024-09942-y
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Abdulraheem, R. A., Martins, R. N., Bharadwaj, P., Li, Z., Coorey, R., Johnson, S., & Fernando, W. M. A. D. B. (2024). Nutrients and polyphenols-rich sorghum bicolor genotypes as complementary therapy for Alzheimer’s disease. Phytochemistry Reviews. Advance online publication. https://doi.org/10.1007/s11101-024-09942-y