Abstract
Introduction: This study investigated whether self-reported sleep quality is associated with brain amyloid beta (AB) accumulation. METHODS: Linear mixed effect model analyses were conducted for 189 cognitively unimpaired (CU) older adults (mean ± standard deviation 74.0 ± 6.2; 53.2% female), with baseline self-reported sleep data, and positron emission tomography-determined brain AB measured over a minimum of three time points (range 33.3–72.7 months). Analyses included random slopes and intercepts, interaction for apolipoprotein E (APOE) 4 allele status, and time, adjusting for sex and baseline age.
Results: Sleep duration < 6 hours, in APOE 4 carriers, and sleep efficiency < 65%, in the whole sample and APOE 4 non-carriers, is associated with faster accumulation of brain AB. DISCUSSION: These findings suggest a role for self-reported suboptimal sleep efficiency and duration in the accumulation of Alzheimer's disease (AD) neuropathology in CU individuals. Additionally, poor sleep efficiency represents a potential route via which individuals at lower genetic risk may progress to preclinical AD. Highlights: In cognitively unimpaired older adults self-report sleep is associated with brain amyloid beta (AB) accumulation. Across sleep characteristics, this relationship differs by apolipoprotein E (APOE) genotype. Sleep duration < 6 hours is associated with faster brain AB accumulation in APOE 4 carriers. Sleep efficiency < 65% is associated with faster brain AB accumulation in APOE 4 non-carriers. Personalized sleep interventions should be studied for potential to slow AB accumulation.
Keywords
AIBL study, Alzheimer's disease, amyloid, apolipoprotein E ε4, positron emission tomography, sleep
Document Type
Journal Article
Date of Publication
4-1-2024
Article Number
e12579
Volume
16
Issue
2
Publication Title
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Publisher
Wiley
School
School of Medical and Health Sciences / Centre for Precision Health
Funding Information
The study has received partial financial support from the Alzheimer's Association (US), the Alzheimer's Drug Discovery Foundation, an anonymous foundation, the Science and Industry Endowment Fund, the Dementia Collaborative Research Centres, the Victorian Government's Operational Infrastructure Support program, the Australian Alzheimer's Research Foundation, the National Health and Medical Research Council (NHMRC), and The Yulgilbar Foundation. Numerous commercial interactions have supported data collection and analyses. In-kind support has also been provided by Sir Charles Gairdner Hospital, Cogstate Ltd, Hollywood Private Hospital, The University of Melbourne, and St Vincent's Hospital. LNP is supported by a Higher Degree by Research scholarship co-funded by Murdoch University and Alzheimer's Research Australia. SRRS is supported by an NHMRC Investigator Grant (GNT1197315).
Funding received from the National Health and Medical Research Council (NHMRC)
GNT1197315
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Pivac, L. N., Brown, B. M., Sewell, K. R., Doecke, J. D., Villemagne, V. L., Doré, V., . . . Rainey-Smith, S. R. (2024). Suboptimal self-reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 16(2), Article e12579. https://doi.org/10.1002/dad2.12579
Comments
Pivac, L. N., Brown, B. M., Sewell, K. R., Doecke, J. D., Villemagne, V. L., Doré, V., . . . Rainey-Smith, S. R. (2024). Suboptimal self-reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 16(2), article e12579. https://doi.org/10.1002/dad2.12579