Document Type
Journal Article
Publication Title
OMICS A Journal of Integrative Biology
Volume
28
Issue
7
First Page
319
Last Page
376
PubMed ID
38841897
Publisher
Mary Ann Liebert
School
Centre for Precision Health / School of Medical and Health Sciences
RAS ID
70389
Funders
Western Australian Future Health Research Fund and Innovation (Grant ID WANMA/Ideas2023-24/10)
Australia-China International Collaborative
Grant Number
NHMRC Number : APP1112767-NSFC 81561128020
Abstract
Systems biology and multiomics research expand the prospects of planetary health innovations. In this context, this mini-review unpacks the twin scholarships of glycomedicine and precision medicine in the current era of single-cell multiomics. A significant growth in glycan research has been observed over the past decade, unveiling and establishing co- and post-translational modifications as dynamic indicators of both pathological and physiological conditions. Systems biology technologies have enabled large-scale and high-throughput glycoprofiling and access to data-intensive biological repositories for global research. These advancements have established glycans as a pivotal third code of life, alongside nucleic acids and amino acids. However, challenges persist, particularly in the simultaneous analysis of the glycome and transcriptome in single cells owing to technical limitations. In addition, holistic views of the complex molecular interactions between glycomics and other omics types remain elusive. We underscore and call for a paradigm shift toward the exploration of integrative glycan platforms and analysis methods for single-cell multiomics research and precision medicine biomarker discovery. The integration of multiple datasets from various single-cell omics levels represents a crucial application of systems biology in understanding complex cellular processes and is essential for advancing the twin scholarships of glycomedicine and precision medicine.
DOI
10.1089/omi.2024.0111
Creative Commons License
This work is licensed under a Creative Commons Attribution-No Derivative Works 4.0 License.
Comments
This is an Author's Accepted Manuscript of Oh, S., Cao, W., & Song, M. (2024). Twin scholarships of glycomedicine and precision medicine in times of single-cell multiomics. OMICS: A Journal of Integrative Biology, 28(7). https://doi.org/10.1089/omi.2024.0111