Twin scholarships of glycomedicine and precision medicine in times of single-cell multiomics

Document Type

Journal Article

Publication Title

OMICS A Journal of Integrative Biology

Volume

28

Issue

7

First Page

319

Last Page

376

PubMed ID

38841897

Publisher

Mary Ann Liebert

School

Centre for Precision Health / School of Medical and Health Sciences

RAS ID

70389

Funders

Western Australian Future Health Research Fund and Innovation

Grant Number

ID WANMA/Ideas2023-24/10

Comments

This is an Author's Accepted Manuscript of Oh, S., Cao, W., & Song, M. (2024). Twin Scholarships of Glycomedicine and Precision Medicine in Times of Single-Cell Multiomics. OMICS: A Journal of Integrative Biology. https://doi.org/10.1089/omi.2024.0111

Abstract

Systems biology and multiomics research expand the prospects of planetary health innovations. In this context, this mini-review unpacks the twin scholarships of glycomedicine and precision medicine in the current era of single-cell multiomics. A significant growth in glycan research has been observed over the past decade, unveiling and establishing co- and post-translational modifications as dynamic indicators of both pathological and physiological conditions. Systems biology technologies have enabled large-scale and high-throughput glycoprofiling and access to data-intensive biological repositories for global research. These advancements have established glycans as a pivotal third code of life, alongside nucleic acids and amino acids. However, challenges persist, particularly in the simultaneous analysis of the glycome and transcriptome in single cells owing to technical limitations. In addition, holistic views of the complex molecular interactions between glycomics and other omics types remain elusive. We underscore and call for a paradigm shift toward the exploration of integrative glycan platforms and analysis methods for single-cell multiomics research and precision medicine biomarker discovery. The integration of multiple datasets from various single-cell omics levels represents a crucial application of systems biology in understanding complex cellular processes and is essential for advancing the twin scholarships of glycomedicine and precision medicine.

DOI

10.1089/omi.2024.0111

Creative Commons License

Creative Commons Attribution-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-No Derivative Works 4.0 License.

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