Document Type
Journal Article
Publication Title
Cardiovascular Diabetology
Volume
23
Issue
1
PubMed ID
38943172
Publisher
Springer
School
Centre for Precision Health / School of Medical and Health Sciences
RAS ID
71182
Funders
Science and Technology Special Fund Projects of Guangdong Province
Grant Number
202053-116, 202053-74
Abstract
Background: The Triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, has been implicated in the risk of ischemic stroke. However, the interplay between TyG levels, lifestyle factors, and their collective impact on stroke risk in non-diabetic populations remains inadequately explored. This study aims to evaluate the association of ischemic stroke with the joint development of the TyG index and lifestyle in the non-diabetic population. Methods: In this prospective cohort study, data was collected across three consecutive biennial surveys of the Kailuan Study from 2006 to 2011. The dual-trajectory model was used to determine the temporal development of TyG levels and lifestyle scores. Statistical analysis involved Cox regression models to evaluate the association between TyG-lifestyle trajectories and ischemic stroke risk, adjusting for potential confounders. Results: A total of 44,403 participants were included, with five distinct TyG levels and lifestyle scores trajectory subtypes identified. In the multivariable-adjusted analyses, significant differences in ischemic stroke risk among the trajectory subtypes. Group 5, characterized by the highest TyG levels and moderate lifestyle scores, exhibited the greatest ischemic stroke risk (HR = 1.81, 95% CI: 1.51–2.18), while group 4, with moderate TyG levels and higher lifestyle scores, demonstrated the lowest risk (HR = 1.19, 95% CI: 1.04–1.37), compared with group 3. Participants with elevated TyG levels were at an increased risk of ischemic stroke in cases of pronounced insulin resistance, even with a healthy lifestyle. Conclusions: This study reveals the significant associations between the identified TyG and lifestyle trajectories and the stratification of ischemic stroke risk among non-diabetics. The TyG index is a valuable indicator for assessing insulin resistance. However, the potential benefits of lifestyle changes for those with significantly high TyG levels need to be clarified by more research to develop more effective stroke prevention strategies.
DOI
10.1186/s12933-024-02313-z
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Zhou, H., Ding, X., Lan, Y., Fang, W., Yuan, X., Tian, Y., ... & Wu, D. (2024). Dual-trajectory of TyG levels and lifestyle scores and their associations with ischemic stroke in a non-diabetic population: A cohort study. Cardiovascular Diabetology, 23(1), 225. https://doi.org/10.1186/s12933-024-02313-z