Document Type
Journal Article
Publication Title
Journal of Alzheimer's Disease Reports
Volume
8
Issue
1
First Page
1009
Last Page
1021
Publisher
IOS Press
School
School of Medical and Health Sciences
Funders
Macquarie University / Australian Alzheimer's Research Foundation / Lions Alzheimer's Foundation
Abstract
Alzheimer's disease (AD) is the most common type of dementia, which is characterised by progressive memory loss and accumulation of hallmark markers amyloid-β (Aβ) and neurofibrillary tangles in the diseased brain. The current gold standard diagnostic methods have limitations of being invasive, costly, and not easily accessible. Thus, there is a need for new avenues, such as imaging the retina for early AD diagnosis. Sleep disruption is symptomatically frequent across preclinical and AD subjects. As circadian activity, such as the sleep-wake cycle, is linked to the retina, analysis of their association may be useful additions for achieving predictive AD diagnosis. In this narrative review, we provide an overview of human retina studies concerning the deposition of Aβ, the role of the retina in sleep-wake cycle, the disruption of sleep in AD, and to gather evidence for the associations between Aβ, the retina, and sleep. Understanding the mechanisms behind the associations between Aβ, retina, and sleep could assist in the interpretation of retinal changes accurately in AD.
DOI
10.3233/ADR-230150
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Comments
De Guia, I. L., Eslick, S., Naismith, S. L., Kanduri, S., Shah, T. M., & Martins, R. N. (2024). The crosstalk between amyloid-β, retina, and sleep for the early diagnosis of Alzheimer’s disease: A narrative review. Journal of Alzheimer's Disease Reports, 8(1), 1009-1021. https://doi.org/10.3233/ADR-230150