Document Type
Journal Article
Publication Title
American Journal of Preventive Medicine
Volume
67
Issue
4
First Page
606
Last Page
617
PubMed ID
38876293
Publisher
Elsevier
School
School of Medical and Health Sciences / Nutrition and Health Innovation Research Institute / School of Arts and Humanities
RAS ID
70343
Funders
National Heart Foundation of Australia (102498, 102817) / National Health and Medical Research Council
Grant Number
NHMRC Numbers : 1172987, 1116973
Abstract
Introduction: Cardiovascular imaging results offer valuable information that can guide health decisions, but their impact on medication use and adherence is unclear. This systematic review and meta-analysis aimed to determine the downstream impact of cardiovascular imaging results on medication use and adherence. Methods: Searches were conducted across databases, including MEDLINE, PsychINFO, EMBASE, and relevant references up to 2024. Data were extracted from studies comparing outcomes for individuals with diseased versus normal arteries and trials comparing outcomes for individuals who were provided imaging results versus those with no access to imaging results and analysed in 2023 and 2024. Pooled odds ratios (ORs) for outcomes were calculated. Results: The analysis included 29 studies with 24 contributing data points. Initiation (OR:2.77;95% CI:1.82–4.20) and continuation (OR:2.06;95% CI:1.28–3.30) of lipid-lowering medications (LLMs), antihypertensives (OR:2.02;95% CI:1.76–2.33), and antiplatelets (OR:2.47;95% CI:1.68–3.64) were significantly higher in individuals with diseased arteries. The proportion of individuals on LLM increased by 2.7-fold in those with diseased arteries and 1.5-fold in those with normal arteries post-screening. The proportion on LLM increased by 4.2 times in the imaging group and 2.2 times in the "no imaging group" post-screening. There was a significant increase in LLM initiation (OR:2.37;95% CI: 1.17–4.79) in the imaging group, but medication continuation did not significantly differ between the imaging and "no imaging group". Discussion: Cardiovascular imaging results can prompt initiation of medications, particularly lipid-lowering medications, reflecting a proactive response to identified risk factors. However, evidence regarding medication continuation is mixed, and further research is required.
DOI
10.1016/j.amepre.2024.06.008
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Anokye, R., Dalla Via, J., Dimmock, J., Jackson, B., Schultz, C., Schæffer, M., ... & Lewis, J. R. (2024). Impact of cardiovascular imaging results on medication use and adherence: A systematic review and meta-analysis. American Journal of Preventive Medicine, 67(4), 606-617. https://doi.org/10.1016/j.amepre.2024.06.008