Author Identifier
Simone Radavelli-Bagatini: https://orcid.org/0000-0001-6821-5217
Catherine P. Bondonno: https://orcid.org/0000-0001-8509-439X
Jack Dalla Via: https://orcid.org/0000-0002-1815-0838
Marc Sim: https://orcid.org/0000-0001-5166-0605
Abadi K. Gebre: https://orcid.org/0000-0002-1975-0085
Lauren C. Blekkenhorst: https://orcid.org/0000-0003-1561-9052
Emma Connolly: https://orcid.org/0000-0003-0171-8236
Nicola P. Bondonno: https://orcid.org/0000-0001-5905-444X
Mandy Stanley: https://orcid.org/0000-0002-7958-5181
Amanda Devine: https://orcid.org/0000-0001-6978-6249
Joshua R. Lewis : https://orcid.org/0000-0003-1003-8443
Moira Sim: https://orcid.org/0000-0001-5962-6639
Jonathan M. Hodgson: https://orcid.org/0000-0001-6184-7764
Document Type
Journal Article
Publication Title
Nature Communications
Volume
15
Issue
1
PubMed ID
39402045
Publisher
Nature
School
Nutrition and Health Innovation Research Institute / School of Medical and Health Sciences
RAS ID
75949
Funders
MRFF Preventive and Public Health (APP1199751) / Royal Perth Hospital Research Foundation Lawrie Beilin Career Advancement Fellowship (CAF 127/2020, RPHRF CAF 00/21) / Western Australian Future Health Research and Innovation Fund (IG2021/5) / Western Australian Future Health Research and Innovation Fund / National Health and Medical Research Council / National Heart Foundation of Australia (102498, 102817) / Australian Government Research Training Program Scholarship at Edith Cowan University
Grant Number
NHMRC Numbers : 1172987, 1116973
Abstract
Provision of non-invasive vascular imaging results to individuals has been shown to improve cardiovascular disease risk factor control: its impact on diet remains uncertain. In this two-arm, single-blind, parallel, 12-week randomized controlled trial, 240 participants, 57.5% females aged 60–80 y had abdominal aortic calcification and clinical assessments performed at a hospital clinic. Participants were randomized 1:1 to receive (intervention n = 121) or not (control n = 119) their calcification results. Both groups received educational resources on cardiovascular disease risk control and were unblinded to the intervention. Outcome measures were performed at baseline and 12 weeks. The primary outcomes of the study were changes in fruit and vegetable intake measures over 12 weeks assessed using plasma carotenoid concentrations (biomarkers of FV intake) and a food frequency questionnaire. Secondary outcomes included 12-week changes in other aspects of the diet, physical activity, body weight, blood pressure, heart rate, lipid profile, glucose concentrations, estimated cardiovascular disease risk score, and medication use. Between-group differences were tested using linear mixed-effects regression. There were no between-group differences in the primary outcomes at 12 weeks: plasma carotenoids (mean difference +0.03 µg/mL [95%CI −0.06, 0.13]) and fruit and vegetable intakes (+18 g/d [−37, 72]). However, the provision of calcification results led to between-group differences in serum total (−0.22 mmol/L [−0.41, −0.04]) and non-HDL (−0.19 mmol/L [−0.35, −0.03]) cholesterol, and estimated cardiovascular disease risk score (−0.24% [−0.47, −0.02]). No between-group differences were seen for other secondary outcomes. In this work, providing vascular imaging results did not improve diet but did improve some cardiovascular disease risk factors (Australian and New Zealand Clinical Trials Registry ACTRN12618001087246).
DOI
10.1038/s41467-024-52172-1
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comments
Radavelli-Bagatini, S., Bondonno, C. P., Dalla Via, J., Sim, M., Gebre, A. K., Blekkenhorst, L. C., ... & Lewis, J. R. (2024). Impact of provision of abdominal aortic calcification results on fruit and vegetable intake: 12-week randomized phase 2 controlled trial. Nature Communications, 15, Article 8126. https://doi.org/10.1038/s41467-024-52172-1