Author Identifier (ORCID)
Simone Radavelli-Bagatini's ORCID record 
Catherine P. Bondonno's ORCID record
Lauren C. Blekkenhorst's ORCID record
Nicola P. Bondonno's ORCID record
Abstract
Provision of non-invasive vascular imaging results to individuals has been shown to improve cardiovascular disease risk factor control: its impact on diet remains uncertain. In this two-arm, single-blind, parallel, 12-week randomized controlled trial, 240 participants, 57.5% females aged 60–80 y had abdominal aortic calcification and clinical assessments performed at a hospital clinic. Participants were randomized 1:1 to receive (intervention n = 121) or not (control n = 119) their calcification results. Both groups received educational resources on cardiovascular disease risk control and were unblinded to the intervention. Outcome measures were performed at baseline and 12 weeks. The primary outcomes of the study were changes in fruit and vegetable intake measures over 12 weeks assessed using plasma carotenoid concentrations (biomarkers of FV intake) and a food frequency questionnaire. Secondary outcomes included 12-week changes in other aspects of the diet, physical activity, body weight, blood pressure, heart rate, lipid profile, glucose concentrations, estimated cardiovascular disease risk score, and medication use. Between-group differences were tested using linear mixed-effects regression. There were no between-group differences in the primary outcomes at 12 weeks: plasma carotenoids (mean difference +0.03 µg/mL [95%CI −0.06, 0.13]) and fruit and vegetable intakes (+18 g/d [−37, 72]). However, the provision of calcification results led to between-group differences in serum total (−0.22 mmol/L [−0.41, −0.04]) and non-HDL (−0.19 mmol/L [−0.35, −0.03]) cholesterol, and estimated cardiovascular disease risk score (−0.24% [−0.47, −0.02]). No between-group differences were seen for other secondary outcomes. In this work, providing vascular imaging results did not improve diet but did improve some cardiovascular disease risk factors (Australian and New Zealand Clinical Trials Registry ACTRN12618001087246).
Keywords
Vascular Imaging, Cardiovascular Risk, Dietary Intake, Randomized Controlled Trial, Cholesterol Levels
Document Type
Journal Article
Date of Publication
12-1-2024
Article Number
8126
Volume
15
Issue
1
PubMed ID
39402045
Publication Title
Nature Communications
Publisher
Nature
School
Nutrition and Health Innovation Research Institute / School of Medical and Health Sciences
RAS ID
75949
Funding Information
This research received funding from an MRFF Preventive and Public Health grant, APP1199751 (2020-2023). CPB was supported by a Royal Perth Hospital Research Foundation Lawrie Beilin Career Advancement Fellowship (ID: CAF 127/2020) and the Western Australian Future Health Research and Innovation Fund (ID: IG2021/5). MS was supported by a Royal Perth Hospital Research Foundation Fellowship (RPHRF CAF 00/21) and an Emerging Leader Fellowship from the Western Australian Future Health Research and Innovation Fund. LCB was supported by a National Health and Medical Research Council (NHMRC) of Australia Emerging Leadership Investigator Grant (ID: 1172987) and a National Heart Foundation of Australia Post-Doctoral Research Fellowship (ID: 102498). ELC was supported by an Australian Government Research Training Program Scholarship at Edith Cowan University. JRL was supported by a National Heart Foundation Future Leader Fellowship (ID: 102817). JMH was supported by an NHMRC of Australia Senior Research Fellowship (ID 1116973). DPK received grants to his institution from Amgen, Radius Health, and Solarea Bio.
Funding received from the National Health and Medical Research Council (NHMRC)
1172987, 1116973
Funding received from the Medical Research Future Fund (MRFF)
APP1199751
Administering Institution
Edith Cowan University
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Content Type
Full object
Recommended Citation
Radavelli-Bagatini, S., Bondonno, C. P., Dalla Via, J., Sim, M., Gebre, A. K., Blekkenhorst, L. C., ... & Lewis, J. R. (2024). Impact of provision of abdominal aortic calcification results on fruit and vegetable intake: 12-week randomized phase 2 controlled trial. Nature Communications, 15, Article 8126. https://doi.org/10.1038/s41467-024-52172-1
Comments
Radavelli-Bagatini, S., Bondonno, C. P., Dalla Via, J., Sim, M., Gebre, A. K., Blekkenhorst, L. C., ... & Lewis, J. R. (2024). Impact of provision of abdominal aortic calcification results on fruit and vegetable intake: 12-week randomized phase 2 controlled trial. Nature Communications, 15, Article 8126. https://doi.org/10.1038/s41467-024-52172-1