Document Type

Journal Article

Publication Title

Journal of the American Heart Association

Volume

13

Issue

20

PubMed ID

39392152

Publisher

Wiley

School

Centre for Precision Health / School of Medical and Health Sciences

Comments

Cui, C., Li, P., Qi, Y., Song, J., Han, T., Shang, X., ... & Wu, Z. (2024). Intraindividual discordance between remnant cholesterol and low‐density lipoprotein cholesterol associated with incident stroke: Results from 2 national cohorts. Journal of the American Heart Association, 13(20). https://doi.org/10.1161/JAHA.124.035764

Abstract

BACKGROUND: The atherogenic effect of remnant cholesterol is being increasingly acknowledged. This study aimed to explore the association of discordance between remnant cholesterol and low-density lipoprotein cholesterol with stroke onset using 2 Chinese national cohorts. METHODS AND RESULTS: We studied 11 139 participants from CHARLS (China Health and Retirement Longitudinal Study) and 5993 participants from CHNS (China Health and Nutrition Survey) aged 45 years or older. The discordance between remnant cholesterol and low-density lipoprotein cholesterol was defined using the difference in percentile units (>15 units). There were 988 (8.9%) and 128 (2.1%) stroke events reported during follow-up in the 2 cohorts. Elevated remnant cholesterol was significantly associated with a higher risk of total stroke in 2 cohorts. After adjusting for remnant cholesterol level, the discordantly high remnant cholesterol group was significantly associated with an increased stroke risk (CHARLS: subdistribution hazard ratio [sHR], 1.31 [95 CI, 1.10–1.55]; CHNS: sHR, 1.84 [95 CI, 1.15–3.08]) compared with the discordantly low group. Consistent results were shown even among those with optimal low-density lipoprotein cholesterol level. CONCLUSIONS: The discordance between remnant cholesterol and low-density lipoprotein cholesterol, representing the intraindividual discrepancy, is significantly associated with stroke onset among Chinese adults.

DOI

10.1161/JAHA.124.035764

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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