Document Type

Journal Article

Publication Title

Alzheimer's and Dementia

Publisher

Wiley

School

Centre of Excellence for Alzheimer's Disease Research and Care / School of Medical and Health Sciences / Centre for Precision Health

RAS ID

75915

Funders

Fonds de Recherche du Québec - Santé / Brain Canada Foundation / Canadian Institute of Health Research; Spanish Institute of Health Carlos III; Korea Health Industry Development Institute; Japan Agency for Medical Research and Development; Deutsches Zentrum für Neurodegenerative Erkrankungen, Grant/Award Number: N/A; National Institute on Aging, Grant/Award Number: U19AG032438; Alzheimer’s Association, Grant/Award Numbers: SG-20-690363-DIAN, AARFD-21-851415; Korea Dementia Research Center; Raul Carrea Institute for Neurological Research

Comments

Sewell, K. R., Doecke, J. D., Xiong, C., Benzinger, T., Masters, C. L., Laske, C., ... & Dominantly Inherited Alzheimer's Network. (2024). Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia, 20(11), 7923-7939. https://doi.org/10.1002/alz.14270

Abstract

INTRODUCTION: We investigated longitudinal associations between self-reported exercise and Alzheimer's disease (AD)-related biomarkers in individuals with autosomal dominant AD (ADAD) mutations. METHODS: Participants were 308 ADAD mutation carriers aged 39.7 ± 10.8 years from the Dominantly Inherited Alzheimer's Network. Weekly exercise volume was measured via questionnaire and associations with brain volume (magnetic resonance imaging), cerebrospinal fluid biomarkers, and brain amyloid beta (Aβ) measured by positron emission tomography were investigated. RESULTS: Greater volume of weekly exercise at baseline was associated with slower accumulation of brain Aβ at preclinical disease stages β = –0.16 [–0.23 to –0.08], and a slower decline in multiple brain regions including hippocampal volume β = 0.06 [0.03 to 0.08]. DISCUSSION: Exercise is associated with more favorable profiles of AD-related biomarkers in individuals with ADAD mutations. Exercise may have therapeutic potential for delaying the onset of AD; however, randomized controlled trials are vital to determine a causal relationship before a clinical recommendation of exercise is implemented. Highlights: Greater self-reported weekly exercise predicts slower declines in brain volume in autosomal dominant Alzheimer's disease (ADAD). Greater self-reported weekly exercise predicts slower accumulation of brain amyloid beta in ADAD. Associations varied depending on closeness to estimated symptom onset.

DOI

10.1002/alz.14270

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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