Document Type

Journal Article

Publication Title

Sports Medicine and Health Science

Publisher

Elsevier

School

Nutrition and Health Innovation Research Institute / School of Medical and Health Sciences

RAS ID

75850

Funders

Edith Cowan University Early-Mid Career Researcher Grant Scheme (G1006474)

Comments

Murphy, M. C., Coventry, M., Taylor, J. L., Rio, E. K., Mosler, A. B., Whittaker, J. L., & Latella, C. (2024). People with hip osteoarthritis have reduced quadriceps voluntary activation and altered motor cortex function. Sports Medicine and Health Science. Advance online publication. https://doi.org/10.1016/j.smhs.2024.09.005

Abstract

Aims: Compare quadriceps voluntary activation, corticospinal and intracortical excitability between people with and without hip osteoarthritis (OA). Exploratory objectives include quantifying the association of corticospinal/intracortical excitability with voluntary activation, corticospinal/intracortical excitability with hip related pain, and motor threshold with motor cortex inhibition and facilitation. Methods: Case-control study including participants with clinically and radiologically confirmed hip OA and non-OA controls. Quadriceps voluntary activation was assessed using twitch interpolation via femoral nerve stimulation. Single- and paired-pulse transcranial magnetic stimulation over the motor cortex assessed resting motor threshold (RMT), active motor threshold (AMT), short-interval intracortical inhibition (SICI), intracortical facilitation (ICF) and silent period. Generalized linear models assessed outcomes (p < 0.05). Results: We included 17 hip OA (76% female) and 24 controls (92% female) with a mean (standard deviation) age of 58.7 (7.9) years. Compared to controls, people with hip OA had reduced quadriceps voluntary activation (β = -5.29, 95% confidence intervals [CI], -0.79–-9.79) and increased ICF (β = 0.22, 95%CI, 0.01–0.43). People with hip OA did not differ from controls in RMT (β = −4.76, 95%CI, −14.08–4.56), AMT (β = −2.13, 95%CI, −7.12-2.86), SICI (β = −0.02, 95%CI, −0.15-0.006) or silent period (β = 8.72, 95%CI, −24.75–42.20). More facilitation was associated with increased hip pain (β = 24.55, 95%CI, 6.93–42.18), and more inhibition was associated with less voluntary activation (β = 10.50, 95%CI, 2.00–18.99). Conclusion: People with hip OA demonstrate reduced quadriceps voluntary activation and complex changes in motor cortex excitability compared to controls. These findings suggest that hip OA can alter quadriceps neuromuscular function (facilitation associated with pain, inhibition associated with activation), thus having implications for rehabilitation.

DOI

10.1016/j.smhs.2024.09.005

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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