Prevalence and management of depressive symptoms in coronary heart disease patients and relationship with cardiovascular prognosis: A prospective cohort study

Authors

Yewei Pan
Yequn Chen
Shenglin Wu
Pengxiang Ying, Edith Cowan UniversityFollow
Zishan Zhang
Xuerui Tan
Jinxiu Zhu

Document Type

Journal Article

Publication Title

BMC Psychiatry

Volume

24

Issue

1

PubMed ID

39350149

Publisher

Springer

School

Centre for Precision Health

RAS ID

72565

Funders

Guangdong Province Science and Technology Special Fund Project (STKJ2021052) / “Dengfeng Project” for the Construction of High-Level Hospitals in Guangdong Province, First Affiliated Hospital of Shantou University Medical College (202003-31)

Comments

Pan, Y., Chen, Y., Wu, S., Ying, P., Zhang, Z., Tan, X., & Zhu, J. (2024). Prevalence and management of depressive symptoms in coronary heart disease patients and relationship with cardiovascular prognosis: A prospective cohort study. BMC Psychiatry, 24, 644. https://doi.org/10.1186/s12888-024-06117-z

Abstract

Aims: Depressive symptoms are comorbid with coronary heart disease (CHD). There is a controversial debate about whether screening and intervention for depressive symptoms could improve cardiovascular prognosis. This study characterizes the prevalence, characteristics, cardiovascular prognosis and management need of depressive symptoms among CHD patients. Methods: CHD patients were recruited between November 18, 2020 and November 26, 2021. Depressive symptoms were evaluated with the Patient Health Questionnaire (PHQ-9). During the 12-month follow-up, cardiovascular disease (CVD) was the endpoint. Time-to-event data were estimated by Kaplan-Meier curves and Cox models. Results: Of 582 patients (25% women), 21.0% had mild depressive symptoms, and 7.5% had moderate-to-severe depressive symptoms during hospitalization. Mild and moderate-to-severe depressive symptoms were risk factor-adjusted predictors of the primary composite endpoints (adjusted HR = 2.20; 95%CI 1.19–4.03, and adjusted HR = 2.70; 95%CI 1.23–5.59, respectively). Platelet count and low-density lipoprotein were higher in mild depressive symptoms compared to no depressive symptoms. Conclusion: Depressive symptoms are prevalent in CHD patients. Mild and moderate-to-severe depressive symptoms are associated with higher risk of further CVD in CHD patients. Platelet function and behavioral mechanisms may contribute to this association. Trial registration: This research was registered at https://www.chictr.org.cn. Full data of first registration is 11/09/2020. The registration number is ChiCTR2000038139.

DOI

10.1186/s12888-024-06117-z

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.