Insulin resistance, cognition and alzheimer's disease biomarkers: Evidence that CSF Aβ42 moderates the association between insulin resistance and increased CSF tau levels
Document Type
Journal Article
Publication Title
Neurobiology of Aging
Volume
114
First Page
38
Last Page
48
Publisher
Elsevier
School
School of Medical and Health Sciences / Centre for Precision Health
RAS ID
43975
Abstract
Mounting evidence implicates insulin resistance (IR) with reduced cognition, increased dementia risk and changes in Alzheimer's disease biomarkers. It's unclear how, and at what stage IR has the greatest impact on Alzheimer's disease biomarker progression indicative of cognitive decline. Exploration of potential factors influencing this relationship continue. We have previously reported IR to be associated with cognitive function, and increased CSF tau in a cognitively unimpaired cohort. Now, we aimed to determine if CSF total (t-tau) or phosphorylated tau (p-tau) mediated the relationship between HOMA-IR and cognition, and explore sex or amyloid-β (Aβ) biomarkers as moderators of this relationship. Mediation analysis demonstrated that CSF tau does not directly influence the association between HOMA-IR and cognition. Moderation analysis revealed CSF Aβ42 moderates the relationships between HOMA-IR and CSF tau. The combination of lower CSF Aβ42 and higher HOMA-IR was associated with increases in CSF tau. The CSF Aβ42 moderation finding has potential to be considered when assessing type 2 diabetic risk for tau pathology and cognitive decline.
DOI
10.1016/j.neurobiolaging.2022.03.004
Access Rights
subscription content
Comments
Woodfield, A., Porter, T., Gilani, I., Noordin, S., Li, Q. X., Collins, S., ... & AIBL Research Group. (2022). Insulin resistance, cognition and Alzheimer's disease biomarkers: Evidence that CSF Aβ42 moderates the association between insulin resistance and increased CSF tau levels. Neurobiology of Aging, 114, 38-48. https://doi.org/10.1016/j.neurobiolaging.2022.03.004