Author Identifier
Albert Stuart Reece: https://orcid.org/0000-0002-3256-720X
Gary Kenneth Hulse: https://orcid.org/0000-0002-7907-0233
Document Type
Journal Article
Publication Title
Addiction Biology
Volume
29
Issue
11
PubMed ID
39538372
Publisher
Wiley
School
School of Medical and Health Sciences
RAS ID
77398
Abstract
Whilst mitochondrial inhibition and micronuclear fragmentation are well established features of the cannabis literature mitochondrial stress and dysfunction has recently been shown to be a powerful and direct driver of micronucleus formation and chromosomal breakage by multiple mechanisms. In turn genotoxic damage can be expected to be expressed as increased rates of cancer, congenital anomalies and aging; pathologies which are increasingly observed in modern continent-wide studies. Whilst cannabinoid genotoxicity has long been essentially overlooked it may in fact be all around us through the rapid induction of aging of eggs, sperm, zygotes, foetus and adult organisms with many lines of evidence demonstrating transgenerational impacts. Indeed this multigenerational dimension of cannabinoid genotoxicity reframes the discussion of cannabis legalization within the absolute imperative to protect the genomic and epigenomic integrity of multiple generations to come.
DOI
10.1111/adb.70003
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Reece, A. S., & Hulse, G. K. (2024). Key insights into cannabis‐cancer pathobiology and genotoxicity. Addiction Biology, 29(11). https://doi.org/10.1111/adb.70003