Prior oral proton-pump inhibitor use is associated with reduced severity of aspirin-related upper gastrointestinal bleeding in older people
Document Type
Journal Article
Publication Title
Internal Medicine Journal
Volume
52
Issue
4
First Page
663
Last Page
666
PubMed ID
35419961
Publisher
Wiley
School
School of Medical and Health Sciences
RAS ID
52186
Abstract
Low-dose aspirin is commonly used for primary or secondary prophylaxis against cardiovascular disease in older people. However, the potential risk of upper gastrointestinal (UGI) ulceration and bleeding associated with low-dose aspirin use is often not appreciated by prescribers and older consumers. Among 133 serial patients with UGI bleeding, aspirin-users aged ≥70 years had a ninefold increased likelihood of overt UGI bleeding compared with non-users, reducing by 90% in regular proton-pump inhibitor users (adjusted odds ratio 0.10). We recommend risk-versus-benefit discussions when recommending aspirin to older people.
DOI
10.1111/imj.15732
Access Rights
subscription content
Comments
Ayonrinde, O. T., Walldorf, N., Chan, N., Foo, N. Y., Kulkarni, T., Olynyk, J. K., & Sanfilippo, F. M. (2022). Prior oral proton‐pump inhibitor use is associated with reduced severity of aspirin‐related upper gastrointestinal bleeding in older people. Internal Medicine Journal, 52(4), 663-666. https://doi.org/10.1111/imj.15732