Prior oral proton-pump inhibitor use is associated with reduced severity of aspirin-related upper gastrointestinal bleeding in older people
Abstract
Low-dose aspirin is commonly used for primary or secondary prophylaxis against cardiovascular disease in older people. However, the potential risk of upper gastrointestinal (UGI) ulceration and bleeding associated with low-dose aspirin use is often not appreciated by prescribers and older consumers. Among 133 serial patients with UGI bleeding, aspirin-users aged ≥70 years had a ninefold increased likelihood of overt UGI bleeding compared with non-users, reducing by 90% in regular proton-pump inhibitor users (adjusted odds ratio 0.10). We recommend risk-versus-benefit discussions when recommending aspirin to older people.
Document Type
Journal Article
Date of Publication
4-1-2022
Volume
52
Issue
4
PubMed ID
35419961
Publication Title
Internal Medicine Journal
Publisher
Wiley
School
School of Medical and Health Sciences
RAS ID
52186
Copyright
subscription content
First Page
663
Last Page
666
Comments
Ayonrinde, O. T., Walldorf, N., Chan, N., Foo, N. Y., Kulkarni, T., Olynyk, J. K., & Sanfilippo, F. M. (2022). Prior oral proton‐pump inhibitor use is associated with reduced severity of aspirin‐related upper gastrointestinal bleeding in older people. Internal Medicine Journal, 52(4), 663-666. https://doi.org/10.1111/imj.15732