Abstract
Sleep discrepancy (negative discrepancy reflects worse self-reported sleep than objective measures, such as actigraphy, and positive discrepancy the opposite) has been linked to adverse health outcomes. This study is first to investigate the relationship between sleep discrepancy and brain glucose metabolism (assessed globally and regionally via positron emission tomography), and to evaluate the contribution of insomnia severity and depressive symptoms to any associations. Using data from cognitively unimpaired community-dwelling older adults (N = 68), cluster analysis was used to characterise sleep discrepancy (for total sleep time (TST), wake after sleep onset (WASO), and sleep efficiency (SE)), and logistic regression was used to explore sleep discrepancy's associations with brain glucose metabolism, while controlling for insomnia severity and depressive symptoms. Lower glucose metabolism across multiple brain regions was associated with negative discrepancy for WASO and SE, and positive discrepancy for WASO only (large effect sizes; β ≥ 0.5). Higher glucose metabolism in the superior parietal and posterior cingulate regions was associated with negative discrepancy for TST (large effect sizes; β ≥ 0.5). These associations remained when controlling for insomnia severity and depressive symptoms, suggesting a unique role of sleep discrepancy as a potential early behavioural marker of brain health.
RAS ID
77471
Document Type
Journal Article
Date of Publication
1-1-2024
Volume
6
Funding Information
Australian Government Research Training Project / National Health and Medical Research Council / The Yulgilbar Foundation (Yulgilbar Alzheimer’s Research Program) / Brain Foundation / Government of Western Australia (Department of Health/Future Health WA Merit Award)
School
School of Medical and Health Sciences
Grant Number
NHMRC Number : GNT1197315
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Publisher
Elsevier
Identifier
Kevin Taddei: https://orcid.org/0000-0002-8106-7957
Hamid R. Sohrabi: https://orcid.org/0000-0001-8017-8682
Ralph N. Martins: https://orcid.org/0000-0002-4828-9363
Stephanie R. Rainey-Smith: https://orcid.org/0000-0001-7328-9624
Comments
Soh, N., Weinborn, M., Doecke, J. D., Canovas, R., Doré, V., Xia, Y., Fripp, J., Taddei, K., Bucks, R. S., Sohrabi, H. R., Martins, R. N., Ree, M., & Rainey-Smith, S. R. (2024). Sleep discrepancy and brain glucose metabolism in community-dwelling older adults. Aging Brain, 6. https://doi.org/10.1016/j.nbas.2024.100130