Role of N-glycosylation in gastrointestinal cancers

Document Type

Journal Article

Publication Title

OMICS A Journal of Integrative Biology

Volume

28

Issue

12

First Page

596

Last Page

607

PubMed ID

39514331

Publisher

Mary Ann Liebert, Inc. Publishers

School

Centre for Precision Health / School of Medical and Health Sciences

RAS ID

76476

Funders

SUMC-ECU / Doctoral Program of Guangdong Science and Technology Special Fund (2020ST066) / Shantou Science and Technology Plan Project (2022NO.81-85) / Western Australian Future Health Research and Innovation Fund (WANMA/Ideas2023-24/10)

Comments

Xu, R., Balmer, L., Chen, G., & Song, M. (2024). Role of N-glycosylation in gastrointestinal cancers. OMICS: A Journal of Integrative Biology, 28(12), 596-607. https://doi.org/10.1089/omi.2024.0174

Abstract

Gastrointestinal cancers pose a significant global health challenge. N-glycosylation modulates various cellular processes, including key cancer-related mechanisms. Elucidating its involvement in the onset and advancement of these cancers can offer critical insights for enhancing diagnostic and therapeutic approaches. This review outlines the core process of protein N-glycosylation and highlights its contribution to the progression of gastrointestinal cancers, encompassing cell proliferation, survival, invasion, metastasis, and immune evasion, mainly through its impact on critical signaling pathways. Notably, aberrant N-glycosylation patterns have emerged as crucial biomarkers for the diagnosis and prognosis of various gastrointestinal cancers, providing the foundation for more personalized therapeutic approaches. Therapeutic strategies targeting N-glycosylation, such as glycosyltransferase inhibitors and glycoengineering, show significant promise in mitigating tumor aggressiveness and enhancing immune recognition. However, the clinical implementation of N-glycosylation biomarkers requires the standardization of glycosylation analysis techniques and solutions to challenges in sample processing and data interpretation. Future research efforts should concentrate on overcoming these obstacles to unlock the full potential of N-glycosylation in enhancing cancer management and advancing patient outcomes.

DOI

10.1089/omi.2024.0174

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