Author Identifier
Zhixian Chen: https://orcid.org/0000-0002-2970-3346
Manshu Song: https://orcid.org/0000-0003-1433-7192
Document Type
Journal Article
Publication Title
OMICS A Journal of Integrative Biology
Volume
28
Issue
12
First Page
608
Last Page
619
PubMed ID
39585210
Publisher
Mary Ann Liebert, Inc. Publishers
School
Centre for Precision Health / School of Medical and Health Sciences
RAS ID
77130
Funders
Basic and Applied Basic Research Foundation of Guangdong Province (2024A1515012910) / Special Funds for Science and Technology of Guangdong Province (210715106900976, 210712096871576) / Western Australian Future Health Research and Innovation Fund (ID WANMA/Ideas2023-24/10)
Abstract
The crosstalk between cytokines and immunoglobulin G (IgG) N-glycosylation forms a bidirectional regulatory network that significantly impacts inflammation and immune function. This review examines how various cytokines, both pro- and anti-inflammatory, modulate IgG N-glycosylation, shaping antibody activity and influencing inflammatory responses. In addition, we explore how altered IgG N-glycosylation patterns affect cytokine production and immune signaling, either promoting or reducing inflammation. Through a comprehensive analysis of current studies, this review underscores the dynamic relationship between cytokines and IgG N-glycosylation. These insights enhance our understanding of the mechanisms underlying inflammatory diseases and contribute to improved strategies for disease prevention, diagnosis, monitoring, prognosis, and the exploration of novel treatment options. By focusing on this crosstalk, we identify new avenues for developing innovative diagnostic tools and therapies to improve patient outcomes in inflammatory diseases.
DOI
10.1089/omi.2024.0176
Creative Commons License
This work is licensed under a Creative Commons Attribution-No Derivative Works 4.0 License.
Comments
This is an Author's Accepted Manuscript of: Chen, Z., Xu, X., Song, M., & Lin, L. (2024). Crosstalk between cytokines and IgG N-Glycosylation: Bidirectional effects and relevance to clinical innovation for inflammatory diseases. OMICS: A Journal of Integrative Biology, 28(12), 608-619. https://doi.org/10.1089/omi.2024.0176