Document Type
Journal Article
Publication Title
JBMR Plus
Publisher
Oxford University Press
School
Nutrition and Health Innovation Research Institute
RAS ID
76537
Funders
National Health and Medical Research Council / Australian Research Council / Defence Science Institute / Royal Perth Hospital Research Foundation Fellowship (RPHRF CAF 00/21) / Western Australian Future Health Research and Innovation Fund / Heart Foundation Postdoctoral Fellowship (Award number: 107194) / National Heart Foundation of Australia Future Leader Fellowship (ID: 102817 & 107323)
Grant Number
NHMRC Number : APP1194159, ARC Numbers : DP190103081, DP200101830
Abstract
Lipocalin-2 (LCN2), a hormone produced by adipocytes, osteoblasts and renal tubular cells, is implicated in age-related diseases, including cardio-metabolic disease. To understand the role LCN2 may play in pathological states, we first need to elucidate the relationship between circulating LCN2 with indices of cardio-metabolic health during “normal” ageing. This study examined the relationship between serum levels of LCN2, age and cardio-metabolic measures across the adult lifespan in males and females. We conducted a pooled cohort analysis including 124 community-dwelling males (n = 52) and females (n = 72) (age 20 - 87 years, median BMI 25.92 (23.04, 29.81) kg/m2). Serum LCN2 was analysed using a two-step chemiluminescent microparticle monoclonal immunoassay. The relationship between LCN2 and age was evaluated by linear regression and cubic spline. Simple linear regressions were performed to investigate the relationship between LCN2 and the following variables: BMI, VO2peak, serum glucose, body composition (dual-energy X-ray absorptiometry). For every 1 year increase in age, LCN2 levels were 0.26 mg/L higher (p = 0.007, 95% CI [0.07, 0.45]). Each 1 unit increase in BMI (kg/m2) was associated with 0.88 mg/L higher LCN2 levels (p = 0.027, [0.10, 1.66]) and each 1 unit increase in VO2peak (mL/kg/min) was associated with 0.38 mg/L lower LCN2 (p = 0.003, [- 0.63, -0.13]).There was no significant relationship between LCN2 and sex, glucose levels or body composition (all p > 0.05). LCN2 increased linearly across the adult lifespan while it decreased as fitness level increased. Future research should build on these findings to determine whether LCN2 can be used as a biomarker for chronic disease and if exercise can mitigate age-related disease associated with LCN2 changes.
DOI
10.1093/jbmrpl/ziae162
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Bauer, C., Smith, C., Vogrin, S., Palmer, A. S., Woessner, M., Landen, S., ... & Levinger, I. (2024). Circulating lipocalin-2 across the adult lifespan. JBMR Plus. Advance online publication. https://doi.org/10.1093/jbmrpl/ziae162