Document Type

Journal Article

Publication Title

Journal of Experimental and Clinical Cancer Research

Volume

44

Issue

1

PubMed ID

39934875

Publisher

Springer

School

Centre for Precision Health / School of Medical and Health Sciences

RAS ID

78180

Funders

MRFF: 2020 Genomics Health Futures Mission GA176020 Integrated Multimodal Precision Liquid Biopsy to enhance MELanoma and NSCLC Treatment (IMPLEMENT)

Comments

Sheriff, S., Saba, M., Patel, R., Fisher, G., Schroeder, T., Arnolda, G., ... & Ellis, L. A. (2025). A scoping review of factors influencing the implementation of liquid biopsy for cancer care. Journal of Experimental & Clinical Cancer Research, 44. https://doi.org/10.1186/s13046-025-03322-w

Abstract

Background: Liquid biopsy (LB) offers a promising, minimally invasive alternative to traditional tissue biopsies in cancer care, enabling real-time monitoring and personalized treatment. Despite its potential, the routine implementation of LB in clinical practice faces significant challenges. This scoping review examines the barriers and facilitators influencing the implementation of liquid biopsies into standard cancer care. Methods: Four academic databases (PubMed, Scopus, Embase, and Web of Science) were systematically searched without language restrictions. We included peer-reviewed articles that were published between January 2019 and March 2024 that focused on the implementation of LB in cancer care or described barriers and facilitators to its implementation. Data relevant to the review objective, including key article characteristics; barriers and facilitators of implementation; and recommendations for advancement or optimisation; were extracted and analysed using thematic and visual network analyses. Results: The majority of the included articles were narrative review articles (84%), with most from China (24.2%) and the United States (20%). Thematic analysis identified four main categories and their associated barriers and facilitators to the implementation of LB in cancer care: (1) Laboratory and personnel requirements; (2) Disease specificity; (3) Biomarker-based liquid biopsy; and (4) Policy and regulation. The majority of barriers identified were concentrated in the pre-analytical phase, highlighting the lack of standardization in LB technologies and outcomes. Conclusions: Through a thematic analysis of the barriers and facilitators to LB implementation, we present an integrated tool designed to encourage the standardization of testing methods for clinical practice guidelines in the field.

DOI

10.1186/s13046-025-03322-w

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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