The moderating effect of diet on the relationship between depressive symptoms and Alzheimer's disease-related blood-based biomarkers
Author Identifier (ORCID)
Samantha L. Gardener: https://orcid.org/0000-0002-1933-5260
Stephanie R. Rainey-Smith: https://orcid.org/0000-0001-7328-9624
Steve Pedrini: https://orcid.org/0000-0002-6409-8022
Hamid R. Sohrabi: https://orcid.org/0000-0001-8017-8682
Kevin Taddei: https://orcid.org/0000-0002-8106-7957
Ralph N. Martins: https://orcid.org/0000-0002-4828-9363
W. M.A.D.Binosha Fernando: https://orcid.org/0000-0002-8364-7808
Abstract
Associations between mental health, diet, and risk of Alzheimer's disease highlight the need to investigate whether dietary patterns moderate the relationship between symptoms of depression and anxiety, and neurodegeneration-related blood-based biomarkers. Cognitively unimpaired participants (n = 89) were included from the Australian Imaging, Biomarkers and Lifestyle study (mean age 75.37; 44 % male). Participants provided dietary, depressive and anxiety symptom data, and had measurement of blood-based biomarkers. Dietary pattern scores (Mediterranean diet (MeDi), Dietary Approaches to Stop Hypertension diet (DASH), and Western diet) were generated. Moderation and simple slope analyses were employed. In males with mean and below mean MeDi adherence, depressive symptoms were associated with higher neurofilament light (NfL) levels. In Apolipoprotein E ε4 non-carriers with lower than mean and mean MeDi adherence, depressive symptoms were associated with higher NfL and Aβ40 levels. No associations were observed between DASH and Western diets and neurodegeneration-related biomarkers. MeDi adherence is potentially a moderator of the relationship between depressive symptoms and neurodegeneration-related blood-based biomarkers, with sex- and genotype-specific approaches important to consider within this relationship.
Document Type
Journal Article
Date of Publication
3-1-2025
Volume
147
PubMed ID
39837054
Publication Title
Neurobiology of Aging
Publisher
Elsevier
School
Centre of Excellence for Alzheimer's Disease Research and Care / School of Medical and Health Sciences
Funders
Alzheimer's Association (US) / Alzheimer's Drug Discovery Foundation / Anonymous Foundation / Science and Industry Endowment Fund / Dementia Collaborative Research Centres / Victorian Government's Operational Infrastructure Support Program / Australian Alzheimer's Research Foundation / National Health and Medical Research Council / The Yulgilbar Foundation / Omani Consulate PhD Scholarship
Grant Number
NHMRC Number : GNT1197315
Copyright
subscription content
First Page
213
Last Page
222
Comments
Al Shamsi, H. S. S., Gardener, S. L., Rainey-Smith, S. R., Pedrini, S., Sohrabi, H. R., Taddei, K., ... & AIBL research group. (2025). The moderating effect of diet on the relationship between depressive symptoms and Alzheimer’s disease-related blood-based biomarkers. Neurobiology of Aging, 147, 213-222. https://doi.org/10.1016/j.neurobiolaging.2025.01.003