Nanao/organocatalyat SiO2/4-(2-Aminoethyl)-morpholine as a new, reusable, and efficacious catalyst for the synthesis of polyhydroquinolines derivatives and antibacterially active evaluation

Authors/Creators

Leila Amiri-Zirtol
Zahra Karimi
Javad Farahbakhsh, Edith Cowan UniversityFollow
Ahmad Gholami
Seyedeh Narjes Abootalebi

Abstract

In this study, a new nanocomposite comprising 4-(2-Aminoethyl)-morpholine, an organic catalyst, was prepared on the surface of silica. The absence of metal in the catalyst structure contributes to its environmental friendliness. This novel nanocatalyst was used for multi-component reactions (MCRs). Having a nano size for the composite enhances the contact between the raw materials and the catalytic surface, leading to significant advancement in the reaction. The synthesized composite was identified and evaluated using FT-IR, EDX, EDX-Mapping, TGA, XRD, BET, TEM, and FE-SEM analysis. The characteristic analysis confirmed the synthesis of both nano-silica/4-(2-Aminoethyl)-morpholine catalyst and polyhydroquinoline. The composite’s catalytic properties for synthesizing some polyhydroquinoline derivatives were investigated, yielding promising and remarkable results with high 95% yields and short reaction times. The antibacterial properties of the synthesized compounds were also examined against four types of pathogenic bacteria. The highest inhibitory effect was attributed to the compound Ethyl-4-(3-hydroxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate exhibited the highest antibacterial properties.

Document Type

Journal Article

Date of Publication

12-1-2025

Volume

19

Issue

1

Funding Information

Shiraz University of Medical Sciences (28484)

School

School of Engineering

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Publisher

Springer

Identifier

Javad Farahbakhsh: https://orcid.org/0000-0002-5032-6493

Comments

Amiri-Zirtol, L., Karimi, Z., Farahbakhsh, J., Gholami, A., & Abootalebi, S. N. (2025). Nanao/organocatalyat SiO2/4-(2-Aminoethyl)-morpholine as a new, reusable, and efficacious catalyst for the synthesis of polyhydroquinolines derivatives and antibacterially active evaluation. BMC Chemistry, 19. https://doi.org/10.1186/s13065-025-01403-7

Recommended Citation

Amiri-Zirtol, L., Karimi, Z., Farahbakhsh, J., Gholami, A., & Abootalebi, S. (2025). Nanao/organocatalyat SiO2/4-(2-Aminoethyl)-morpholine as a new, reusable, and efficacious catalyst for the synthesis of polyhydroquinolines derivatives and antibacterially active evaluation. DOI: https://doi.org/10.1186/s13065-025-01403-7