Author Identifier

Javad Farahbakhsh: https://orcid.org/0000-0002-5032-6493

Document Type

Journal Article

Publication Title

BMC Chemistry

Volume

19

Issue

1

Publisher

Springer

School

School of Engineering

Publication Unique Identifier

10.1186/s13065-025-01403-7

Funders

Shiraz University of Medical Sciences (28484)

Comments

Amiri-Zirtol, L., Karimi, Z., Farahbakhsh, J., Gholami, A., & Abootalebi, S. N. (2025). Nanao/organocatalyat SiO2/4-(2-Aminoethyl)-morpholine as a new, reusable, and efficacious catalyst for the synthesis of polyhydroquinolines derivatives and antibacterially active evaluation. BMC Chemistry, 19. https://doi.org/10.1186/s13065-025-01403-7

Abstract

In this study, a new nanocomposite comprising 4-(2-Aminoethyl)-morpholine, an organic catalyst, was prepared on the surface of silica. The absence of metal in the catalyst structure contributes to its environmental friendliness. This novel nanocatalyst was used for multi-component reactions (MCRs). Having a nano size for the composite enhances the contact between the raw materials and the catalytic surface, leading to significant advancement in the reaction. The synthesized composite was identified and evaluated using FT-IR, EDX, EDX-Mapping, TGA, XRD, BET, TEM, and FE-SEM analysis. The characteristic analysis confirmed the synthesis of both nano-silica/4-(2-Aminoethyl)-morpholine catalyst and polyhydroquinoline. The composite’s catalytic properties for synthesizing some polyhydroquinoline derivatives were investigated, yielding promising and remarkable results with high 95% yields and short reaction times. The antibacterial properties of the synthesized compounds were also examined against four types of pathogenic bacteria. The highest inhibitory effect was attributed to the compound Ethyl-4-(3-hydroxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate exhibited the highest antibacterial properties.

DOI

10.1186/s13065-025-01403-7

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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