Author Identifier

Jonathan Hodgson: https://orcid.org/0000-0001-6184-7764

Document Type

Journal Article

Publication Title

Nutrients

Volume

17

Issue

5

PubMed ID

40077737

Publisher

MDPI

School

Nutrition and Health Innovation Research Institute / School of Medical and Health Sciences

Publication Unique Identifier

10.3390/nu17050869

Funders

The University of Western Australia / Curtin University / The Kids Research Institute Australia / Women and Infants Research Foundation / Edith Cowan University / Murdoch University / The University of Notre Dame Australia/ National Health and Medical Research Council / Canadian Institutes of Health Research (MOP-82893) / WA Health, Government of Western Australia Future Health (G06302) / Flinders University

Grant Number

NHMRC Numbers : 353514, 572613, 403981, 1059711, 634445, 1022134, 634509, 1027449, 1044840, 1021858

Comments

Woodman, R., Mangoni, A. A., Cohen-Woods, S., Mori, T. A., Beilin, L., Murphy, K., & Hodgson, J. (2025). Patterns of dietary fatty acids and fat spreads in relation to blood pressure, lipids and insulin resistance in young adults: A repeat cross-sectional study. Nutrients, 17(5), 869. https://doi.org/10.3390/nu17050869

Abstract

Background/Objectives: Determining whether dietary fatty acids and the use of fat spreads are associated with cardiovascular risk factors is difficult due to the multicollinearity of fatty acids and the consumption of multiple spread types. Methods: We applied clustering methodologies using data on 31 different fatty acids and 5 different types of fat spreads (high fat: butter, blended butters, and margarines; lower fat: polyunsaturated and monounsaturated) and investigated associations with blood pressure, serum lipid patterns and insulin resistance in the Raine Study Gen2 participants in Western Australia, at 20 and 22 years of age. Results: Amongst n = 785 participants, there were eight distinct clusters formed from the fatty acid data and ten distinct clusters formed from the fat spread data. Male participants had higher systolic blood pressure than females (122.2 ± 11.6 mmHg versus 111.7 ± 10.3, p < 0.001 at age 20 and 123.4 ± 10.6 versus 113.9 ± 9.8, p < 0.001 at age 22). Males consuming exclusively butter as a fat spread had significantly higher SBP (+4.3 mmHg) compared with males not using spreads. Males consuming a high intake of margarine had significantly higher SBP (+6.6 mmHg), higher DBP (+3.4 mmHg) and higher triglycerides (+30.5%). Amongst females, four patterns of fatty acid intake were associated with lower levels of HDL cholesterol compared with the low-saturated-fat/high n-3 reference group (p = 0.017 after adjustment for relevant confounders, range = −10.1% to −16.0%, p = 0.017). There were no associations between clusters and HOMA-IR or other serum lipids for males or females. Conclusions: Compared to using no fat spreads, amongst males, a high intake of margarine was characterised by higher systolic and diastolic blood pressure and higher serum triglycerides, whilst the use of butter also was associated with higher SBP. Diets low in n-3s or high in trans fats were associated with sub-optimal HDL levels amongst females.

DOI

10.3390/nu17050869

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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