A turning point in cardiac remodelling in obesity: Obesity

Authors

Mariella R. Huaman
Carlos J. Toro-Huamanchumo, Edith Cowan UniversityFollow

Author Identifier

Carlos J. Toro-Huamanchumo: https://orcid.org/0000-0002-4664-2856

Document Type

Journal Article

Publication Title

Nature Reviews Cardiology

Volume

22

Publisher

Nature

School

Nutrition and Health Innovation Research Institute

Funders

Forrest Research Foundation Scholarship / Edith Cowan University

Comments

This is an Author's Accepted Manuscript of: Huaman, M. R., & Toro-Huamanchumo, C. J. (2025). A turning point in cardiac remodelling in obesity. Nature Reviews Cardiology, 22, 398.https://doi.org/10.1038/s41569-025-01154-x

Abstract

Cardiac remodelling in obesity has received growing attention in the past two decades, particularly as the prevalence of obesity continues to rise globally. In 2013, Aurigemma and colleagues published a seminal study that provided crucial insights into the structural changes in the heart associated with obesity. This study summarized advances in understanding how the disproportionate growth of adipose tissue affects cardiac function, and challenged and reshaped previously established paradigms. Before the publication of this report, the standard paradigm held that obesity-induced haemodynamic stress primarily drove eccentric left ventricular hypertrophy. However, this study instead demonstrated that in individuals with obesity, concentric left ventricular remodelling might be at least as common as eccentric remodelling, and that concentric remodelling often precedes or coexists with subclinical impairment of myocardial function.

DOI

10.1038/s41569-025-01154-x

Creative Commons License

This work is licensed under a Creative Commons Attribution-No Derivative Works 4.0 License.