Author Identifier
Cassandra Smith: https://orcid.org/0000-0002-2517-2824
Document Type
Journal Article
Publication Title
Current Osteoporosis Reports
Volume
23
Issue
1
PubMed ID
40210790
Publisher
Springer
School
Nutrition and Health Innovation Research Institute / School of Medical and Health Sciences
RAS ID
82002
Abstract
Purpose of Review: This review summarises the latest evidence on effects of exercise on falls prevention, bone mineral density (BMD) and fragility fracture risk in postmenopausal women, explores hypotheses underpinning exercise-mediated effects on BMD and sheds light on innovative concepts to better understand and harness the skeletal benefits of exercise. Recent Findings: Multimodal exercise programs incorporating challenging balance exercises can prevent falls. Emerging clinical trial evidence indicates supervised progressive high-intensity resistance and impact training (HiRIT) is efficacious in increasing lumbar spine BMD and is safe and well-tolerated in postmenopausal women with osteoporosis/osteopenia. There remains uncertainty regarding durability of this load-induced osteogenic response and safety in patients with recent fractures. Muscle-derived myokines and small circulating extracellular vesicles have emerged as potential sources of exercise-induced muscle-bone crosstalk but require validation in postmenopausal women. Summary: Exercise has the potential for multi-modal skeletal benefits with i) HiRIT to build bone, and ii) challenging balance exercises to prevent falls, and ultimately fractures. The therapeutic effect of such exercise in combination with osteoporosis pharmacotherapy should be considered in future trials.
DOI
10.1007/s11914-025-00912-7
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Kumar, S., Smith, C., Clifton-Bligh, R. J., Beck, B. R., & Girgis, C. M. (2025). Exercise for postmenopausal bone health–Can we raise the bar?. Current Osteoporosis Reports, 23. https://doi.org/10.1007/s11914-025-00912-7