Abstract

Background and aims: Investigating modifiable risk factors, such as diet, is crucial in understanding their effects on the relationship between Alzheimer's disease (AD)-related cognitive decline and related conditions. This study assesses whether dietary patterns moderate the relationship between symptoms of depression, anxiety, and cognitive function in older adults. Given that biological and psychosocial differences between sexes may influence dietary behaviours, mental health symptoms, and cognitive outcomes, conducting sex-stratified analyses will allow for identification of differential associations. Method: Cross-sectional data from cognitively unimpaired older adults (n = 1174, age ≥60 years) from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study were included. Participants completed the Cancer Council of Victoria food frequency questionnaire, provided depression and anxiety symptom data, and underwent neuropsychological testing. Composite scores for six cognitive domains were generated from individual test scores (episodic recall, recognition, executive function, language, attention processing, and the AIBL Preclinical Alzheimer Cognitive Composite (PACC)). Dietary pattern scores were calculated for the Mediterranean diet (MeDi), Dietary Approaches to Stop Hypertension (DASH), and Western diet. Moderation analysis explored interactions between dietary patterns, depression, anxiety, and cognitive performance. Results: The MeDi was found to moderate the relationship between depressive symptoms and attention processing in males, where low to moderate MeDi adherence was linked to poorer attention with higher depressive symptoms. The Western diet moderated the relationship between anxiety and the AIBL PACC score in males, with high adherence to the Western diet associated with worse PACC performance in those with greater anxiety. No significant moderating effects were observed in females for the MeDi and Western diet, or in either sex for the DASH diet on the association of depression and anxiety with cognitive function. Conclusion: These findings also emphasise the importance of sex-specific approaches in research on symptoms of depression and anxiety, cognitive health, and diet. Our results highlight the need for further investigation into sex-specific pathways using longitudinal study designs and randomised controlled trials to establish causal relationships.

RAS ID

82645

Document Type

Journal Article

Date of Publication

8-1-2025

Volume

51

Funding Information

Alzheimer’s Association / the Alzheimer’s Drug Discovery Foundation / Anonymous Foundation / Science and Industry Endowment Fund / Dementia Collaborative Research Centres / Victorian Government’s Operational Infrastructure Support Program / Australian Alzheimer’s Research Foundation / National Health and Medical Research Council / The Yulgilbar Foundation / Omani Consulate

School

Centre of Excellence for Alzheimer's Disease Research and Care / School of Medical and Health Sciences

Grant Number

NHMRC Number : GNT1197315

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Publisher

Elsevier

Comments

Shamsi, H. S. S. A., Gardener, S. L., Sohrabi, H. R., Taddei, K., Masters, C. L., Rainey-Smith, S. R., Martins, R. N., & Fernando, W. M. a. D. B. (2025). The moderating effect of dietary patterns on the association of depression and anxiety with cognitive function. Clinical Nutrition, 51, 278–286. https://doi.org/10.1016/j.clnu.2025.06.013

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