Prevalent vertebral fracture is associated with incident cardiovascular disease events in older individuals referred for bone densitometry

Author Identifier (ORCID)

Syed Zulqarnain Gilani: https://orcid.org/0000-0002-7448-2327

Joshua R. Lewis: https://orcid.org/0000-0003-1003-8443

Abstract

Background: It is unknown if prevalent vertebral fracture (PVFx) captured on bone density vertebral fracture assessment (VFA) images predicts incident CVD events. Methods: 11,760 individuals (mean [SD] age 75.7 [6.8] years, 94 % female) had VFA contemporaneously with bone densitometry in Manitoba, Canada, between February 2010 and December 2017, of whom 1919 (16.3 %) had ≥1 PVFx. This cohort was followed over a mean (SD) 3.8 (2.3) years for Major Adverse Cardiovascular Events (MACE, composite of hospitalization for myocardial infarction, non-hemorrhagic stroke, or all-cause mortality) and other CVD events (hospitalization for coronary artery disease, congestive heart failure, peripheral vascular disease, or coronary bypass/stenting). Proportional hazards models were used to estimate hazard ratios (HR) for incident MACE and other CVD events in those with compared to those without PVFx. Results: Adjusted for age and sex, those with PVFx had HR for incident MACE of 1.34 (95 % C·I. 1.19, 1.51), hospitalization for myocardial infarction (HR 1.35, 95 % C.I. 1.02, 1.79), all-cause mortality (HR 1.36, 95 % C.I, 1.19, 1.56), and other CVD events (HR 1.40, 95 % C.I. 1.21, 1.61). These associations were only slightly attenuated with further adjustment for prior CVD disease and additional CVD risk factors. Conclusion: Prevalent vertebral fracture identified on VFA images in routine clinical practice is robustly associated with incident MACE, independent of other risk factors including AAC which can be simultaneously ascertained on the same images. VFA may have utility for prediction of fractures and CVD outcomes via ascertainment of both prevalent vertebral fracture and AAC.

Document Type

Journal Article

Date of Publication

11-1-2025

Volume

200

Publication Title

Bone

Publisher

Elsevier

School

Nutrition and Health Innovation Research Institute / Centre for Artificial Intelligence and Machine Learning (CAIML) / School of Science

Funders

Rady Innovation Fund / Rady Faculty of Health Sciences / University of Manitoba / National Health and Medical Research Council / Medical Research Future Fund 2022 Cardiovascular Health Mission Grant (MRF2024225) / National Heart Foundation Future Leader Fellowship (107323)

Grant Number

NHMRC Number : APP1183570

Comments

Schousboe, J. T., Monchka, B. A., Davidson, J. M., Kimelman, D., Gilani, S. Z., Ilyas, Z., Reid, S., Lewis, J. R., & Leslie, W. D. (2025). Prevalent vertebral fracture is associated with incident cardiovascular disease events in older individuals referred for bone densitometry. Bone, 200, 117601. https://doi.org/10.1016/j.bone.2025.117601

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Link to publisher version (DOI)

10.1016/j.bone.2025.117601