Intake of total, classes, and subclasses of (poly)phenols and risk of lymphoid neoplasms: A prospective analysis in the EPIC cohort
Author Identifier (ORCID)
Nicola P. Bondonno: https://orcid.org/0000-0001-5905-444X
Abstract
Background: Existing epidemiological evidence regarding the potential role of (poly)phenol intake in lymphoma development is limited. Methods: We investigated the associations between the intake of total and individual classes and subclasses of (poly)phenols and the risk of lymphoma, including main frequent subtypes in the EPIC cohort using multivariable-adjusted Cox proportional hazards models. Results: During a mean 14-year follow-up (time frame: from 1990–1994 to 2008–2013), 2394 incident lymphoma cases were diagnosed from a total of 367,463 individuals. No significant associations were observed between total intakes of (poly)phenols, flavonoids, and phenolic acids and overall lymphoma risk. Total (poly)phenols, phenolic acid and hydroxycinnamic acid intakes were positively associated with Hodgkin lymphoma (HL) risk [HRlog2 = 2.56 (95% confidence interval: 1.27–5.16); 1.81 (1.14–2.87); and 1.48 (1.03–2.12), respectively]. Conversely, isoflavone intakes was inversely associated with risk of overall lymphoma [HRlog2 = 0.96 (0.93–0.99)], and non-Hodgkin lymphoma [HRlog2 = 0.95 (0.92–0.99)] and mature B-cell lymphoma [HRlog2 = 0.96 (0.92–0.99)], and flavone intakes with risk of multiple myeloma/plasma cell neoplasm [HRlog2 = 0.75 (0.60–0.95)]. Conclusions: Our findings suggest that isoflavone intakes may reduce the risk of overall lymphoma and specific lymphoma subtypes, while phenolic acids, particularly hydroxycinnamic acids might increase the risk of HL.
Document Type
Journal Article
Date of Publication
1-1-2025
PubMed ID
41044175
Publication Title
British Journal of Cancer
Publisher
Nature
School
Nutrition and Health Innovation Research Institute / School of Medical and Health Sciences
RAS ID
88051
Funders
Instituto de Salud Carlos III (CIBERESP CB06/02/0073, PI20/00288) / Government of Catalonia (2021SGR01354) / Cancer Research UK (14136, C8221/A29017) / Medical Research Council (1000143, MR/M012190/1) / National Health and Medical Research Council / Danish Cancer Society / Ligue Contre le Cancer / Institut Gustave Roussy / Mutuelle Générale de l’Education Nationale / Institut National de la Santé et de la Recherche Médicale / German Cancer Aid / German Cancer Research Center / German Institute of Human Nutrition Potsdam-Rehbruecke / Federal Ministry of Education and Research / Associazione Italiana per la Ricerca sul Cancro / Compagnia di SanPaolo / National Research Council / Dutch Ministry of Public Health, Welfare and Sports / Netherlands Cancer Registry / LK Research Funds / Dutch Prevention Funds / Dutch ZON / World Cancer Research Fund / Statistics Netherlands
Grant Number
NHMRC Number : APP1159914
Copyright
subscription content
Comments
Almanza-Aguilera, E., Guananga-Álvarez, D., Benavente, Y., Nieters, A., Besson, C., Hosnijeh, F. S., Kyrø, C., Bondonno, N. P., Dahm, C. C., Weiderpass, E., Truong, T., Louati-Hajji, M., Ren, X., Katzke, V., Schulze, M. B., Pasanisi, F., Vener, C., Masala, G., Giraudo, M. T., . . . Casabonne, D. (2025). Intake of total, classes, and subclasses of (poly)phenols and risk of lymphoid neoplasms: a prospective analysis in the EPIC cohort. British Journal of Cancer, 133, 1864–1871. https://doi.org/10.1038/s41416-025-03228-6