Prognostic value of a plasma protein-based biomarker test for chronic kidney disease complicating diabetes in Aboriginal Australians

Abstract

The predictive value of PromarkerD tests for incident diabetic kidney disease or rapid decline in estimated glomerular filtration rate was evaluated in 1010 non-Aboriginal and 71 Aboriginal adults with diabetes. Areas under the receiver operating characteristic curves were not significantly different (P ≥ 0.081) for first- (non-Aboriginals 0.890 (95% confidence interval 0.864 to 0.915) and Aboriginals 0.769 (0.624 to 0.915)) and second-generation (0.890 (0.862 to 0.917) and 0.711 (0.543 to 0.878)) tests. PromarkerD has potential renal prognostic value in Aboriginals with diabetes.

Document Type

Journal Article

Date of Publication

1-1-2025

Publication Title

Internal Medicine Journal

Publisher

Wiley

School

Kurongkurl Katitjin

Funders

National Health and Medical Research Council / Australian Centre for Accelerating Diabetes Innovations / Western Australian State Government in partnership with Bioplatforms Australia under the Commonwealth Government National Collaborative Research Infrastructure Strategy / Medical Research Future Fund Practitioner Fellowship (1154192)

Grant Number

NHMRC Numbers : 513781, 1042231

Comments

Davis, T. M. E., Peters, K. E., Bringans, S., McAullay, D., Singh, A., Lipscombe, R. J., & Davis, W. A. (2025). Prognostic value of a plasma protein‐based biomarker test for chronic kidney disease complicating diabetes in Aboriginal Australians. Internal Medicine Journal. Advance online publication. https://doi.org/10.1111/imj.70275

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Link to publisher version (DOI)

10.1111/imj.70275