Beyond maternal exercise: Paternal exercise adaptations mediated by sperm microRNA signatures

Author Identifier (ORCID)

Daniel A. Galvão: https://orcid.org/0000-0002-8209-2281

Abstract

Preclinical and clinical evidence shows that maternal exercise can contribute to the cardiometabolic health of offspring. Recent tantalizing findings also point to several paternal factors, notably sperm microRNAs, that can mediate the intergenerational transmission of exercise benefits.

Keywords

Maternal exercise, paternal exercise, sperm micrornas, epigenetic inheritance, cardiometabolic health, intergenerational effects

Document Type

Journal Article

Date of Publication

1-1-2026

PubMed ID

41896621

Publication Title

Nature Reviews Urology

Publisher

Nature

School

Exercise Medicine Research Institute / School of Medical and Health Sciences

Funders

PERC Systems Biology Fund / Wereld Kanker Onderzoek Fonds, as part of the World Cancer Research Fund (IIG_FULL_2021_007) / Grant JDC2024-053872-I, funded by MICIU/AEI/10.13039/501100011033 and by the FSE+

Comments

Plaza-Florido, A., Pérez-Prieto, I., Galvão, D. A., & Lucia, A. (2026). Beyond maternal exercise: Paternal exercise adaptations mediated by sperm microRNA signatures. Nature Reviews Urology. Advance online publication. https://doi.org/10.1038/s41585-026-01138-7

Copyright

subscription content

Link to Full Text

Share

 
COinS
 

Link to publisher version (DOI)

10.1038/s41585-026-01138-7