Author Identifier (ORCID)
Abstract
Laparoscopic liver biopsy (LLB) provides a way to obtain liver tissue samples under direct visual inspection of the liver surface. It complements percutaneous liver biopsy (PLB) for complex or high-risk cases where PLB cannot be performed. Clinical practices for LLB vary across centers due to the lack of international standards. To improve the procedural quality and diagnostic efficiency of LLB, a multidisciplinary panel of 45 international experts from 6 continents, including hepatology, hepatobiliary surgery, gastrointestinal surgery, and metabolic and bariatric surgery, developed this consensus statement through three rounds of a modified Delphi process. This consensus covers clinical application scenarios, high-risk clinical scenarios, preoperative preparation, surgical procedures, complication management, and discharge and quality management. It aims to promote the standardization, safety, and rational clinical application of LLB; support the management of complex cases; and facilitate the appropriate implementation of this important diagnostic procedure.
Keywords
consensus statement, Delphi survey, diagnostic procedure, laparoscopic liver biopsy, liver biopsy, liver disease
Document Type
Journal Article
Date of Publication
6-16-2026
Article Number
102831
Volume
7
Issue
6
PubMed ID
42173098
Publication Title
Cell Reports Medicine
Publisher
Elsevier
School
Nutrition and Health Innovation Research Institute
Funding Information
This work was funded by grants from Noncommunicable Chronic Diseases-National Science and Technology Major Project (2026ZD0557000), National Key R&D Program of China (2023YFA1800801), and the National Natural Science Foundation of China (82070588, 82370577). J.G. is supported by the Robert W. Storr Bequest to the Sydney Medical Foundation, University of Sydney; National Health and Medical Research Council of Australia (APP1053206); Investigator and MRFF grants (APP2032407, NCRI000183, APP2016215, APP2010795, and APP1196492); and a Cancer Institute, NSW grant (2021/ATRG2028). C.J.T-H. is supported by the Forrest Research Foundation Scholarship and the Edith Cowan University (ECU) Higher Degree by Research Scholarship. M. Muthiah is supported by the Singapore Ministry of Health through the National Medical Research Council (NMRC) Office, MOH Holdings Pte Ltd under the NMRC Clinician Scientist-Individual Research Grant (MOH-001228), and NMRC Clinician Scientist Award (MOH-001631), as well as the National Research Foundation, Singapore (NRF) under the NMRC Open Fund-Large Collaborative Grant (MOH-001325) and administered by the Singapore Ministry of Health through the NMRC Office, MOH Holdings Pte Ltd.
Funding received from the Medical Research Future Fund (MRFF)
APP2032407, NCRI000183, APP2016215, APP2010795, APP1196492
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Recommended Citation
Lei, S., Han, Y., Rockey, D. C., Alswat, K., Wong, V. W., Jumaev, N., Toro-Huamanchumo, C. J., Taha, S., El-Kassas, M., George, J., Muthiah, M., Ghanem, O., Yoneda, M., Hang, D. V., Sebastiani, G., Papatheodoridis, G., Abu-Abeid, A., Robertson, A. G., Kim, S. H., . . . Zheng, M. (2026). An international multidisciplinary consensus statement on laparoscopic liver biopsy. Cell Reports Medicine, 7(6), 102831. https://doi.org/10.1016/j.xcrm.2026.102831