Development and internal validation of a vectorcardiography-augmented model for 12-month major adverse cardiovascular events in chronic heart failure
Author Identifier (ORCID)
Abstract
To develop and internally validate a vectorcardiography (VCG)–augmented model for estimating 12-month major adverse cardiovascular events (MACE) in hospitalized patients with chronic heart failure (CHF). We conducted a single-centre retrospective cohort study of adults hospitalized with CHF between 31 May 2023 and 31 May 2024, with data lock on 31 May 2025. The prespecified endpoint was any MACE within 12 months after the index hospitalization. ECG-to-VCG transformation was performed using the Kors method. The prespecified primary six-predictor model included LVEDD, NYHA class, frontal, horizontal, and sagittal QRS–T angles, and the QRS-loop reversal/U-turn sign. BNP and LVEF were evaluated in full-model, comparator-model, and incremental-value analyses. Because the prediction target was fixed 12-month risk rather than time-to-event hazard, multivariable logistic regression was used as the primary modelling approach. Internal validation was performed using 1000 bootstrap resamples, with apparent, optimism-corrected, calibration, and shrinkage-adjusted performance reported. Of 201 screened, 160 were included; MACE occurred in 68/160 (42.5%). The six-predictor model showed an apparent AUC of 0.946 (95% CI 0.914–0.978). Bootstrap internal validation yielded an AUC optimism estimate of 0.012 and an optimism-corrected AUC of 0.934. The apparent Brier score was 0.091, the apparent calibration slope was 1.000, and the apparent calibration intercept was 0.000. After bootstrap correction, the Brier score was 0.106, calibration-in-the-large was − 0.009, calibration intercept was − 0.010, calibration slope was 0.852, and the applied uniform shrinkage factor was 0.852. In formal incremental analyses, adding VCG features to a conventional base model improved AUC from 0.890 to 0.955 (ΔAUC 0.065; DeLong P = 0.001), with a lower Brier score and favourable discrimination/reclassification indices. A VCG-augmented model incorporating LVEDD, NYHA class, spatial QRS–T angles, and the QRS-loop reversal/U-turn sign showed promising internally validated performance for estimating 12-month MACE risk in hospitalized patients with CHF. External multicentre validation is required before clinical implementation.
Keywords
chronic heart failure, prognostic model, QRS-loop reversal, QRS–T angle, u-turn sign, vectorcardiography
Document Type
Journal Article
Date of Publication
12-1-2026
Article Number
104
ISSN
01485598
Volume
50
PubMed ID
42377587
Publication Title
Journal of Medical Systems
Publisher
Springer
School
School of Medical and Health Sciences
Copyright
subscription content
Content Type
Metadata only
Recommended Citation
Cen, K., He, Z., Chen, H., Tan, Y., Lin, L., & Xu, X. (2026). Development and internal validation of a vectorcardiography-augmented model for 12-month major adverse cardiovascular events in chronic heart failure. Journal of Medical Systems, 50, Article 104. https://doi.org/10.1007/s10916-026-02432-y