S100/CD34-positive spindle cell mesenchymal neoplasm harboring KIAA1549-BRAF fusion
Document Type
Journal Article
Publication Title
The American Journal of Dermatopathology
Volume
43
Issue
3
First Page
217
Last Page
220
PubMed ID
33464748
Publisher
Wolters Kluwer
School
School of Medical and Health Sciences
Abstract
ABSTRACT: Mesenchymal neoplasms with oncogenic kinase activity due to genomic alterations in receptor tyrosine kinase genes are a morphologically heterogeneous group with a variable biologic potential. A subset of these neoplasms are characterized by immunophenotypic property of dual S100 protein/CD34 expression, histopathological resemblance to lipofibromatosis or peripheral nerve sheath tumors, and often alterations in neurotrophic tropomyosin-related kinase genes. In this article, we present a case of an S100 protein/CD34-positive spindle cell neoplasm harboring a rare BRAF gene rearrangement (KIAA1549-BRAF fusion) and discuss the clinical, histopathological, and molecular variations associated with such neoplasms.
DOI
10.1097/DAD.0000000000001796
Access Rights
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Comments
Paton, D. J., Wong, D., Amanuel, B., Cheah, K., & Ardakani, N. M. (2021). S100/CD34-positive spindle cell mesenchymal neoplasm harboring KIAA1549-BRAF fusion. The American Journal of Dermatopathology, 43(3), 217-220. https://doi.org/10.1097/DAD.0000000000001796