S100/CD34-positive spindle cell mesenchymal neoplasm harboring KIAA1549-BRAF fusion

Abstract

ABSTRACT: Mesenchymal neoplasms with oncogenic kinase activity due to genomic alterations in receptor tyrosine kinase genes are a morphologically heterogeneous group with a variable biologic potential. A subset of these neoplasms are characterized by immunophenotypic property of dual S100 protein/CD34 expression, histopathological resemblance to lipofibromatosis or peripheral nerve sheath tumors, and often alterations in neurotrophic tropomyosin-related kinase genes. In this article, we present a case of an S100 protein/CD34-positive spindle cell neoplasm harboring a rare BRAF gene rearrangement (KIAA1549-BRAF fusion) and discuss the clinical, histopathological, and molecular variations associated with such neoplasms.

Document Type

Journal Article

Date of Publication

2021

Volume

43

Issue

3

PubMed ID

33464748

School

School of Medical and Health Sciences

Copyright

subscription content

Publisher

Wolters Kluwer

Comments

Paton, D. J., Wong, D., Amanuel, B., Cheah, K., & Ardakani, N. M. (2021). S100/CD34-positive spindle cell mesenchymal neoplasm harboring KIAA1549-BRAF fusion. The American Journal of Dermatopathology, 43(3), 217-220. https://doi.org/10.1097/DAD.0000000000001796

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Link to publisher version (DOI)

10.1097/DAD.0000000000001796