Association of IgG glycosylation and esophageal precancerosis beyond inflammation

Abstract

This study aimed to investigate the association of IgG glycosylation and esophageal precancerosis for squamous cell carcinoma and determine its role in inflammation. Primary glycans selected by the least absolute shrinkage and selection operator (LASSO) algorithm were validated using univariate and multivariate logistics models plus restricted cubic spline functions. In total, 24 direct glycans and 27 derived traits were detected, among which four glycans and three derived traits were primarily selected. Then, GP5 (adjusted OR: 0.805), GP17 (adjusted OR: 1.305), G12n (adjusted OR: 1.271), Gal_1 (adjusted OR: 0.776) and Fuc (adjusted OR: 0.737) were validated and significantly associated with esophageal precancerosis. In addition, there was a consistent positive association in GP17 and G12n and a negative association in GP5, Gal_1, and Fuc by restricted cubic spline function. Compared with esophageal inflammation, GP17, G12n, and Fuc were still independently associated with precancerosis. In brief, the IgG glycosylation profile was independently associated with esophageal precancerosis beyond inflammation, which could be an early biomarker for esophageal cancer.

RAS ID

35628

Document Type

Journal Article

Date of Publication

2021

Volume

14

Issue

3

School

School of Medical and Health Sciences

Copyright

subscription content

Publisher

American Association for Cancer Research

Comments

Wu, Z., Pan, H., Liu, D., Zhou, D., Tao, L., Zhang, J., ... Guo, X. (2021). Association of IgG glycosylation and esophageal precancerosis beyond inflammation. Cancer Prevention Research, 14(3), 347-354. https://doi.org/10.1158/1940-6207.CAPR-20-0489

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Link to publisher version (DOI)

10.1158/1940-6207.CAPR-20-0489