Plasma amyloid‐beta levels in a pre‐symptomatic dutch‐type hereditary cerebral amyloid angiopathy pedigree: A cross‐sectional and longitudinal investigation

Authors

Pratishtha Chatterjee, Edith Cowan UniversityFollow
Michelle Tegg, Edith Cowan UniversityFollow
Steve Pedrini, Edith Cowan UniversityFollow
Anne M. Fagan
Chengjie Xiong
Abhay K. Singh
Kevin Taddei, Edith Cowan UinversityFollow
Samantha Gardener, Edith Cowan UniversityFollow
Colin L. Masters
Peter R. Schofield
Gerhard Multhaup
Tammie L. S. Benzinger
John C. Morris
Randall J. Bateman
Steven M. Greenberg
Mark A. van Buchem
Erik Stoops
Hugo Vanderstichele
Charlotte E. Teunissen
Graeme J. Hankey
Marieke J. H. Wermer
Hamid R. Sohrabi, Edith Cowan UniversityFollow
Ralph N. Martins, Edith Cowan UniversityFollow
the Dominantly Inherited Alzheimer Network

Document Type

Journal Article

Publication Title

International Journal of Molecular Sciences

Volume

22

Issue

6

First Page

1

Last Page

12

Publisher

MDPI

School

School of Medical and Health Sciences

RAS ID

39617

Funders

National Health and Medical Research Council National Institute of Health Dominantly Inherited Alzheimer Network study

Grant Number

NHMRC Number : APP1129627

Grant Link

http://purl.org/au-research/grants/nhmrc/1129627

Comments

Chatterjee, P., Tegg, M., Pedrini, S., Fagan, A. M., Xiong, C., Singh, A. K., ... & Martins, R. N. (2021). Plasma amyloid‐beta levels in a pre‐symptomatic dutch‐type hereditary cerebral amyloid angiopathy pedigree: A cross‐sectional and longitudinal investigation. International Journal of Molecular Sciences, 22(6), article 2931. https://doi.org/10.3390/ijms22062931

Abstract

Plasma amyloid‐beta (Aβ) has long been investigated as a blood biomarker candidate for Cerebral Amyloid Angiopathy (CAA), however previous findings have been inconsistent which could be attributed to the use of less sensitive assays. This study investigates plasma Aβ alterations between pre‐symptomatic Dutch‐type hereditary CAA (D‐CAA) mutation‐carriers (MC) and non-carriers (NC) using two Aβ measurement platforms. Seventeen pre‐symptomatic members of a D‐ CAA pedigree were assembled and followed up 3–4 years later (NC = 8;MC = 9). Plasma Aβ1‐40 and Aβ1‐42 were cross‐sectionally and longitudinally analysed at baseline (T1) and follow‐up (T2) and were found to be lower in MCs compared to NCs, cross‐sectionally after adjusting for covari-ates, at both T1(Aβ1‐40: p = 0.001; Aβ1‐42: p = 0.0004) and T2 (Aβ1‐40: p = 0.001; Aβ1‐42: p = 0.016) employing the Single Molecule Array (Simoa) platform, however no significant differences were observed using the xMAP platform. Further, pairwise longitudinal analyses of plasma Aβ1‐40 revealed decreased levels in MCs using data from the Simoa platform (p = 0.041) and pairwise longitudinal analyses of plasma Aβ1‐42 revealed decreased levels in MCs using data from the xMAP platform (p = 0.041). Findings from the Simoa platform suggest that plasma Aβ may add value to a panel of biomarkers for the diagnosis of pre‐symptomatic CAA, however, further validation studies in larger sample sets are required.

DOI

10.3390/ijms22062931

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.