Document Type
Journal Article
Publication Title
Metabolites
Volume
11
Issue
3
Publisher
MDPI
School
School of Medical and Health Sciences
RAS ID
35498
Funders
Australian Catholic University
Abstract
Dynamic changes in circulating and tissue metabolites and lipids occur in response to exercise-induced cellular and whole-body energy demands to maintain metabolic homeostasis. The metabolome and lipidome in a given biological system provides a molecular snapshot of these rapid and complex metabolic perturbations. The application of metabolomics and lipidomics to map the metabolic responses to an acute bout of aerobic/endurance or resistance exercise has dramatically expanded over the past decade thanks to major analytical advancements, with most exercise-related studies to date focused on analyzing human biofluids and tissues. Experimental and analytical con-siderations, as well as complementary studies using animal model systems, are warranted to help overcome challenges associated with large human interindividual variability and decipher the breadth of molecular mechanisms underlying the metabolic health-promoting effects of exercise. In this review, we provide a guide for exercise researchers regarding analytical techniques and experimental workflows commonly used in metabolomics and lipidomics. Furthermore, we discuss advancements in human and mammalian exercise research utilizing metabolomic and lipidomic approaches in the last decade, as well as highlight key technical considerations and remaining knowledge gaps to continue expanding the molecular landscape of exercise biology.
DOI
10.3390/metabo11030151
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Belhaj, M. R., Lawler, N. G., & Hoffman, N. J. (2021). Metabolomics and lipidomics: Expanding the molecular landscape of exercise biology. Metabolites, 11(3), article 151. https://doi.org/10.3390/metabo11030151