Document Type
Journal Article
Publication Title
Digestive and Liver Disease
Publisher
Elsevier
School
School of Medical and Health Sciences
RAS ID
32516
Funders
Core funding for the Raine Study is provided by the University of Western Australia, Curtin University, Telethon Kids Institute, Women and Infants Research Foundation, Edith Cowan University, Murdoch University, The University of Notre Dame Australia and the Raine Medical Research Foundation. Data collection and biological specimens at the 14 and 17-year follow-up were funded by the National Health and Medical Research Council (Programme grants 003209 and 353514; Project grants 211912, 403981 and 1021105).
Abstract
Background and Aims
The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing in young populations. However, there are inadequate data regarding diagnosis of NAFLD. We aimed to validate three scoring systems against a previous standard of suprailiac skinfold thickness for diagnosing NAFLD in population-based adolescents.
Methods
Seventeen-year-old adolescents (n = 899), participating in the Raine Study, attended a cross-sectional follow-up. NAFLD was diagnosed using liver ultrasound. Scores for Fatty liver index (FLI), Hepatic Steatosis Index (HSI) and Zhejiang University index (ZJU index) were calculated. Diagnostic accuracy of these diagnostic tests was evaluated through discrimination and calibration.
Results
NAFLD was diagnosed 9% in males and 15% in females. The three scoring systems demonstrated better discrimination performance for NAFLD in males (AUC was FLI:0.82, HSI: 0.83 and ZJU index: 0.83) compared to females (AUC was FLI: 0.67, HSI: 0.67 and ZJU index: 0.67). Suprailiac skinfold performed better than the scoring systems (overall AUC: 0.82; male AUC:0.88; female AUC:0.73). FLI had best calibration performance.
Conclusion
Suprailiac skinfold thickness was a better predictor of ultrasound-diagnosed NAFLD than the three diagnostic scoring systems investigated. The higher performance characteristics of the algorithmic scoring systems in males compared with females may have implications for use in population assessments.
DOI
10.1016/j.dld.2020.11.037
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comments
This is an Author's Accepted Manuscript of: Wan, F., Pan, F., Ayonrinde, O. T., Adams, L. A., Mori, T. A., Beilin, L. J., ... & Oddy, W. H. (2021). Validation of fatty liver disease scoring systems for ultrasound diagnosed non-alcoholic fatty liver disease in adolescents. Digestive and Liver Disease, 53(6), 746-752.
https://doi.org/10.1016/j.dld.2020.11.037