N-glycosylation profiling of Type 2 diabetes mellitus from baseline to follow-up: An observational study in a Ghanaian population

Abstract

Aim: The study sought to determine the patterns of N-glycan profiles among Type 2 diabetes mellitus (T2DM) patients over a 6-month period. Materials & methods: Biochemical and clinical data were obtained from 253 T2DM patients at baseline and follow-up. Ultra-performance liquid chromatography and statistical methods were applied for N-glycan profiling. Results: The coefficients of variation were 28% and 29% at baseline and follow-up, respectively, whereas the range of N-glycan variability was from 11% to 56%. Apart from GP1 (FA2) and GP29 (FA3G3S [3,3,3]3), the intra-individual variations of N-glycan peaks were not statistically significant. Conclusion: N-glycan profiles were stable over 6-month period in T2DM patients and could be used to monitor biochemical changes in relation with T2DM comorbidities.

RAS ID

35548

Document Type

Journal Article

Date of Publication

2021

Volume

14

Issue

14

School

School of Medical and Health Sciences / School of Science / Centre for People, Place and Planet

Copyright

subscription content

Publisher

Future Medicine

Comments

Adua, E., Memarian, E., Afrifa-Yamoah, E., Russell, A., Trbojević-Akmačić, I., Gudelj, I., ... Wang, W. (2021). N-glycosylation profiling of type 2 diabetes mellitus from baseline to follow-up: An observational study in a Ghanaian population. Biomarkers in Medicine, 15(7), 467-480. https://doi.org/10.2217/bmm-2020-0615

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Link to publisher version (DOI)

10.2217/bmm-2020-0615