N-glycosylation profiling of Type 2 diabetes mellitus from baseline to follow-up: An observational study in a Ghanaian population

Document Type

Journal Article

Publication Title

Biomarkers in Medicine

Volume

14

Issue

14

Publisher

Future Medicine

School

School of Medical and Health Sciences / School of Science / Centre for People, Place and Planet

RAS ID

35548

Comments

Adua, E., Memarian, E., Afrifa-Yamoah, E., Russell, A., Trbojević-Akmačić, I., Gudelj, I., ... Wang, W. (2021). N-glycosylation profiling of type 2 diabetes mellitus from baseline to follow-up: An observational study in a Ghanaian population. Biomarkers in Medicine, 15(7), 467-480. https://doi.org/10.2217/bmm-2020-0615

Abstract

Aim: The study sought to determine the patterns of N-glycan profiles among Type 2 diabetes mellitus (T2DM) patients over a 6-month period. Materials & methods: Biochemical and clinical data were obtained from 253 T2DM patients at baseline and follow-up. Ultra-performance liquid chromatography and statistical methods were applied for N-glycan profiling. Results: The coefficients of variation were 28% and 29% at baseline and follow-up, respectively, whereas the range of N-glycan variability was from 11% to 56%. Apart from GP1 (FA2) and GP29 (FA3G3S [3,3,3]3), the intra-individual variations of N-glycan peaks were not statistically significant. Conclusion: N-glycan profiles were stable over 6-month period in T2DM patients and could be used to monitor biochemical changes in relation with T2DM comorbidities.

DOI

10.2217/bmm-2020-0615

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