What is T+? A gordian knot of tracers, thresholds, and topographies

Authors/Creators

Victor L. Villemagne, Edith Cowan UniversityFollow
Brian J. Lopresti
Vincent Doré
Dana Tudorascu
Milos D. Ikonomovic
Samantha Burnham
Davneet Minhas
Tharick A. Pascoal
N. Scott Mason
Beth Snitz
Howard Aizenstein
Chester A. Mathis
Oscar Lopez
Christopher C. Rowe
William E. Klunk
Ann D. Cohen

Abstract

In this review we examine, in the context of the amyloid, tau, and neurodegeneration framework, the available evidence and potential alternatives on how to establish tau positivity (T+) for multiple tau-imaging tracers in order to reach a consensus on normal and abnormal tau imaging values that can be universally implemented in clinical research and therapeutic trials.

RAS ID

45150

Document Type

Journal Article

Date of Publication

2021

Volume

62

Issue

5

PubMed ID

33384320

School

School of Medical and Health Sciences

Copyright

subscription content

Publisher

Society of Nuclear Medicine and Molecular Imaging

Comments

Villemagne, V. L., Lopresti, B. J., Doré, V., Tudorascu, D., Ikonomovic, M. D., Burnham, S., ... Cohen, A. D. (2021). What is T+? A gordian knot of tracers, thresholds, and topographies. Journal of Nuclear Medicine, 62(5), 614-619. https://doi.org/10.2967/jnumed.120.245423

Recommended Citation

Villemagne, V. L., Lopresti, B. J., Doré, V., Tudorascu, D., Ikonomovic, M. D., Burnham, S., Minhas, D., Pascoal, T. A., Mason, N., Snitz, B., Aizenstein, H., Mathis, C. A., Lopez, O., Rowe, C. C., Klunk, W. E., & Cohen, A. D. (2021). What is T+? A gordian knot of tracers, thresholds, and topographies. DOI: https://doi.org/10.2967/jnumed.120.245423