What is T+? A gordian knot of tracers, thresholds, and topographies

Authors/Creators

• Victor L. Villemagne, Edith Cowan UniversityFollow
• Brian J. Lopresti
• Vincent Doré
• Dana Tudorascu
• Milos D. Ikonomovic
• Samantha Burnham
• Davneet Minhas
• Tharick A. Pascoal
• N. Scott Mason
• Beth Snitz
• Howard Aizenstein
• Chester A. Mathis
• Oscar Lopez
• Christopher C. Rowe
• William E. Klunk
• Ann D. Cohen

Abstract

In this review we examine, in the context of the amyloid, tau, and neurodegeneration framework, the available evidence and potential alternatives on how to establish tau positivity (T+) for multiple tau-imaging tracers in order to reach a consensus on normal and abnormal tau imaging values that can be universally implemented in clinical research and therapeutic trials.

Keywords

Alzheimer disease, AT(N) framework, biomarkers, brain imaging, tau imaging

Document Type

Journal Article

Date of Publication

2021

Volume

62

Issue

5

PubMed ID

33384320

Publication Title

Journal of Nuclear Medicine

Publisher

Society of Nuclear Medicine and Molecular Imaging

School

School of Medical and Health Sciences

RAS ID

45150

Comments

Villemagne, V. L., Lopresti, B. J., Doré, V., Tudorascu, D., Ikonomovic, M. D., Burnham, S., ... Cohen, A. D. (2021). What is T+? A gordian knot of tracers, thresholds, and topographies. Journal of Nuclear Medicine, 62(5), 614-619. https://doi.org/10.2967/jnumed.120.245423

Copyright

subscription content

First Page

614

Last Page

619