Author Identifier
Shane Fernandez
https://orcid.org/0000-0002-4881-245X
Samantha C. Burnham
https://orcid.org/0000-0003-4805-5193
Madeline Peretti
https://orcid.org/0000-0003-3937-8812
Hamid R. Sohrabi
https://orcid.org/0000-0001-8017-8682
Ralph N. Martins
https://orcid.org/0000-0002-4828-9363
Stephanie R. Rainey-Smith
https://orcid.org/0000-0001-7328-9624
Tenielle Porter
https://orcid.org/0000-0002-7887-6622
Simon M. Laws
Document Type
Journal Article
Publication Title
Journal of Alzheimer's Disease Reports
Volume
5
Issue
1
First Page
111
Last Page
120
Publisher
IOS Press
School
School of Medical and Health Sciences / Centre for Precision Health / Centre of Excellence for Alzheimer's Disease Research and Care
RAS ID
35718
Funders
Edith Cowan University
National Health and Medical Research Council
Funding information : https://doi.org/10.3233/ADR-200246
Grant Number
NHMRC Number : APP1161706
Abstract
Background: Genetic variation in Spondin-1, specifically rs11023139, has been associated with reduced rates of cognitive decline in individuals with Alzheimer's disease. Objective: The aim of this study was to assess whether the association was present in cognitively normal older adults. Methods: Longitudinal cognitive decline was investigated using linear mixed modelling in a cohort of 590 cognitively normal older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Study. Results: No independent effect of Spondin-1 rs11023139 on cognitive decline was observed. However, significant associations were observed for the interaction between Apolipoprotein E (APOE) ϵ4 and rs11023139 in individuals with high amyloid-β burden. APOE ϵ4/rs11023139-A carriers declined significantly faster than APOE ϵ4/rs11023139-G-G carriers in measures of global cognition (p=0.011) and verbal episodic memory (p=0.020). Conclusion: These results suggest that carriage of the Spondin-1 rs11023139-A allele significantly contributes to a worsening of cognitive performance in APOE ϵ4 cognitively normal older adults with a high neocortical amyloid-β burden.
DOI
10.3233/ADR-200246
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Comments
Fernandez, S., Burnham, S. C., Milicic, L., Savage, G., Maruff, P., Peretti, M., ... Laws, S. M. (2021). SPON1 is associated with amyloid-β and APOE ε4-related cognitive decline in cognitively normal adults. Journal of Alzheimer's Disease Reports, 5(1), 111-120. https://doi.org/10.3233/ADR-200246