Document Type

Journal Article

Publication Title

Cancers

Volume

13

Issue

14

Publisher

MDPI

School

School of Medical and Health Sciences / Exercise Medicine Research Institute

RAS ID

36194

Funders

Edith Cowan University - Open Access Support Scheme 2021

Australian Government Research Training Program Scholarship / Vice-Chancellor Professional Research Fellowship / Cancer Council of Western Australia / National Health and Medical Research Council /Centre of Research Excellence in Prostate Cancer Survivorship

Comments

Wilson, R. L., Taaffe, D. R., Newton, R. U., Hart, N. H., Lyons-Wall, P., & Galvão, D. A. (2021). Maintaining weight loss in obese men with prostate cancer following a supervised exercise and nutrition program—a pilot study. Cancers, 13(14), Article 3411.

https://doi.org/10.3390/cancers13143411

Abstract

Supervised exercise and nutrition programs can mitigate or reverse androgen deprivation therapy (ADT) induced fat mass (FM) gain, lean mass (LM) loss, and impaired physical function. It is unclear whether these benefits are retained following transition to self-management. This study examined the effect of a home-based weight maintenance program on body composition and physical function in obese men with prostate cancer (PCa) on ADT following a 12-week supervised weight loss intervention. Eleven obese PCa patients (74 ± 5 years, 40.0 ± 4.9% body fat) on ADT ( > 6 months) com-pleted a 12-week self-managed home-based weight maintenance program consisting of 150 min/week of aerobic and resistance training while maintaining a healthy balanced diet. Body composition (DXA), muscle strength (1RM), and cardiorespiratory fitness (400 m walk) were assessed. Significant reductions in weight (−2.8 ± 3.2 kg) and FM (−2.8 ± 2.6 kg), preservation of LM (−0.05 ± 1.6 kg), and improvements in muscle strength and VO2max were achieved across the supervised intervention. Across the home-based program, no significant changes were observed in weight (−0.6 ± 2.8 kg, p = 0.508), FM (0.2 ± 1.4 kg, p = 0.619), LM (−0.8 ± 1.6 kg, p = 0.146), muscle strength (−0.2 to 4.1%, p = 0.086–0.745), or estimated VO2max (0.3 ± 2.1 mL/min/kg, p = 0.649). Self-managed, home-based exercise and nutrition programs are a viable strategy to promote maintenance of body composition and physical function following a supervised intervention in obese PCa patients on ADT.

DOI

10.3390/cancers13143411

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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