Antimicrobial resistance in Clostridioides difficile

Abstract

Antimicrobial resistance (AMR) in Clostridioides difficile remains a significant threat to global healthcare systems, not just for the treatment of C. difficile infection (CDI), but as a reservoir of AMR genes that could be potentially transferred to other pathogens. The mechanisms of resistance for several antimicrobials such as metronidazole and MLSB-class agents are only beginning to be elucidated, and increasingly, there is evidence that previously unconsidered mechanisms such as plasmid-mediated resistance may play an important role in AMR in this bacterium. In this review, the genetics of AMR in C. difficile will be described, along with a discussion of the factors contributing to the difficulty in clearly determining the true burden of AMR in C. difficile and how it affects the treatment of CDI.

RAS ID

38786

Document Type

Journal Article

Date of Publication

2021

Funding Information

Australian Government Research Training Program Scholarship National Health and Medical Research Council Raine Medical Research Foundation

School

School of Medical and Health Sciences

Grant Number

NHMRC Number : APP1138257

Copyright

subscription content

Publisher

Springer

Comments

O’Grady, K., Knight, D. R., & Riley, T. V. (2021). Antimicrobial resistance in Clostridioides difficile. European Journal of Clinical Microbiology & Infectious Diseases, 40(12), 2459-2478. https://doi.org/10.1007/s10096-021-04311-5

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Link to publisher version (DOI)

10.1007/s10096-021-04311-5