Abstract
Reduction of the risk of asthma attacks is a major goal of current asthma management. We propose to derive a risk scale predicting asthma attacks based on the blood eosinophil count and exhaled nitric oxide. Biomarker-stratified trial-level attack rates were extracted and pooled from the control arms of the Novel START, CAPTAIN, QUEST, Benralizumab Phase 2b, PATHWAY, STRATOS 1-2 and DREAM trials (n=3051). These were used to derive rate ratios and the predicted asthma attack rate for different patient groups. The resultant prototype risk scale shows potential to predict asthma attacks, which may be prevented by anti-inflammatory treatment.
Document Type
Journal Article
Date of Publication
2022
Publication Title
Thorax
Publisher
BMJ Publishing Group
School
School of Medical and Health Sciences
RAS ID
38858
Funders
Oxford Respiratory NIHR BRC Welcome Trust
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Couillard, S., Laugerud, A., Jabeen, M., Ramakrishnan, S., Melhorn, J., Hinks, T., & Pavord, I. (2022). Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide. Thorax, 77(2), 199-202. https://doi.org/10.1136/thoraxjnl-2021-217325